CACNB4 and CTBP2

Data Source:
BioGRID (two hybrid)

		CACNB4	CTBP2
Description		calcium voltage-gated channel auxiliary subunit beta 4	C-terminal binding protein 2
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cytoplasmic Side Of Plasma Membrane Synapse	Nucleus Transcription Repressor Complex Photoreceptor Ribbon Synapse Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse Presynaptic Cytosol
	Molecular Function	Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity	RNA Polymerase II Transcription Corepressor Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Kinase Binding Retinoic Acid Receptor Binding Protein-containing Complex Binding NAD Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Chemical Synaptic Transmission Neuromuscular Junction Development Membrane Depolarization Cardiac Conduction Calcium Ion Transmembrane Transport Regulation Of Voltage-gated Calcium Channel Activity	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Synaptic Vesicle Docking Viral Genome Replication Positive Regulation Of Chromatin Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Maintenance Of Presynaptic Active Zone Structure White Fat Cell Differentiation Cellular Response To Leukemia Inhibitory Factor
Pathways		Presynaptic depolarization and calcium channel opening NCAM1 interactions	Repression of WNT target genes Signaling by TCF7L2 mutants
Drugs		Ergocalciferol Enflurane Ranolazine Phenytoin Topiramate Nimodipine Spironolactone Magnesium sulfate Levomenthol Miconazole Amiodarone Mibefradil Dronedarone Trimebutine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases		Episodic ataxias Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Idiopathic dilated cardiomyopathy ( 29495422) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)	Adult body size ( 32376654) Age-related cognitive decline (visuospatial skill) (slope of z-scores) ( 30954325) Apolipoprotein A1 levels ( 32203549) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Height ( 25429064) Hemoglobin levels ( 32327693) Infant, child and juvenile death in continuous marriage (proportion of children died <15 years) ( 30188897) Menarche (age at onset) ( 25231870) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 18264096) Red blood cell count ( 32888494) Refractive error ( 32231278) Vigorous physical activity ( 29899525)
Interacting Genes		12 interacting genes: CACNA1A CBX3 CCDC102B CTBP2 EFHC2 FASLG MAP1A MED31 PTN REM1 SYT1 TBL3	99 interacting genes: ACTG1 AKTIP APP BAZ2B BCAS3 BCL3 C15orf39 CACNB1 CACNB2 CACNB3 CACNB4 CAPN7 CASP8AP2 CATSPER1 CBX4 CCDC120 CCNH CCR5 CDKN2A CEP68 CSTF2 CTBP1 CTPS2 DMRTB1 DTNB DUSP21 DVL2 EEF1D EGLN3 EIF4G1 ELAC2 ENKD1 EP300 FHL3 FLI1 FOXP2 FUNDC1 GLIS2 H3-4 HEMGN HIC1 HOXA5 HOXB5 HOXC5 IKZF1 IKZF2 KCNIP3 KLF3 KLF8 KYNU LCORL LMO4 MDM2 MECOM MSRB3 NEK6 NOL4 NOL4L NRIP1 PLCB1 PNN PPP1R15A PROX1 PSMF1 QARS1 RAI2 RBBP8NL RIMBP3 RNF135 RPL17 RPL7A RPS28 RPS29 RPS4X SDCBP SHISA6 SOX13 SOX6 STUB1 STX11 TEAD3 TGIF1 TLE5 TRIML2 TSHZ3 UBC UBE2I VRTN XRCC6 ZBP1 ZBTB18 ZBTB42 ZEB1 ZEB2 ZFPM1 ZFPM2 ZNF512B ZNF750 ZSCAN4
Entrez ID		785	1488
HPRD ID		09057	04016
Ensembl ID		ENSG00000182389	ENSG00000175029
Uniprot IDs		A0A1B0GTK1 A0A1B0GTP5 A0A1B0GTX8 H0Y476 O00305	P56545
PDB IDs		2D46	2OME 4LCJ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?