CACNA1A and EHMT2

Data Source:
BioGRID (two hybrid)

		CACNA1A	EHMT2
Description		calcium voltage-gated channel subunit alpha1 A	euchromatic histone lysine methyltransferase 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Integral Component Of Membrane Cell Projection Neuronal Cell Body Synapse	Chromatin Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Amyloid-beta Binding Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding	RNA Polymerase II Transcription Corepressor Binding P53 Binding Protein Binding Zinc Ion Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Histone Methyltransferase Activity (H3-K27 Specific) C2H2 Zinc Finger Domain Binding Promoter-specific Chromatin Binding
	Biological Process	Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Cell Death Regulation Of Ion Transmembrane Transport Regulation Of Insulin Secretion Modulation Of Chemical Synaptic Transmission Membrane Depolarization Calcium Ion Import Calcium Ion Transmembrane Transport Response To Amyloid-beta Cellular Response To Amyloid-beta	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Replication DNA Methylation Cellular Response To Starvation Histone Methylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Histone H3-K9 Methylation Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Presynaptic depolarization and calcium channel opening Regulation of insulin secretion	Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Methylation RNA Polymerase I Transcription Initiation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6
Drugs		Ergocalciferol Enflurane Phenytoin Spironolactone Magnesium sulfate Verapamil Levomenthol Loperamide Bepridil Ziconotide Dotarizine Trimebutine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin
Diseases		Episodic ataxias Familial or sporadic hemiplegic migraine Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)	Anti-thyroid drug induced agranulocytosis ( 27157822) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Chronic hepatitis B infection ( 25802187 23760081) Chronotype ( 30696823) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Economic and political preferences (environmentalism) ( 22566634) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 28067908) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Takayasu arteritis ( 25604533) Type 2 diabetes ( 29358691) Ulcerative colitis ( 28067908) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count ( 32888494)
Interacting Genes		92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233	59 interacting genes: ABHD17A ANKRD28 ATF7IP AURKA CACNA1A CCDC33 CHCHD2 CSNK2A1 CUX1 DNMT3A E4F1 EIF4A3 EPDR1 ESR1 FAM161A H1-1 H1-5 H3-3B H3-4 H3C1 H3C14 H3C15 HGS HIC2 ITGB5 KLF12 KLF3 KLF6 LASP1 LIG1 LIMS1 LMO2 LNX1 MX2 NAA10 NAA11 NAPRT PLOD3 PRRC2B PSMA1 PTGER4 RD3 RELB RERE RPA1 RUVBL2 THAP7 TP53 VEZF1 WIZ XAGE2 ZBTB38 ZNF446 ZNF462 ZNF512B ZNF688 ZNF775 ZNF785 ZNF837
Entrez ID		773	10919
HPRD ID		03004	06854
Ensembl ID		ENSG00000141837	ENSG00000204371
Uniprot IDs		A0A087WW63 B5TYJ1 O00555 Q9NS89	A0A024RCN9 A2ABF8 B7Z852 Q59FM7 Q96KQ7
PDB IDs		3BXK	2O8J 3DM1 3K5K 3RJW 4NVQ 5JHN 5JIN 5JIY 5JJ0 5T0K 5T0M 5TTF 5TUY 5V9I 5VSC 5VSE 6MM1
Enriched GO Terms of Interacting Partners?
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