CACNA1A and NELFCD

Data Source:
BioGRID (two hybrid)

		CACNA1A	NELFCD
Description		calcium voltage-gated channel subunit alpha1 A	negative elongation factor complex member C/D
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Integral Component Of Membrane Cell Projection Neuronal Cell Body Synapse	Nucleoplasm Membrane NELF Complex
	Molecular Function	Amyloid-beta Binding Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding	RNA Binding Protein Binding
	Biological Process	Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Cell Death Regulation Of Ion Transmembrane Transport Regulation Of Insulin Secretion Modulation Of Chemical Synaptic Transmission Membrane Depolarization Calcium Ion Import Calcium Ion Transmembrane Transport Response To Amyloid-beta Cellular Response To Amyloid-beta	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription
Pathways		Presynaptic depolarization and calcium channel opening Regulation of insulin secretion	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs		Ergocalciferol Enflurane Phenytoin Spironolactone Magnesium sulfate Verapamil Levomenthol Loperamide Bepridil Ziconotide Dotarizine Trimebutine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin
Diseases		Episodic ataxias Familial or sporadic hemiplegic migraine Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)	Mean platelet volume ( 32888494 27863252) Platelet distribution width ( 27863252)
Interacting Genes		92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233	21 interacting genes: AAMP AR ARAF ARPC4 CACNA1A CDSN DNAJA1 ENDOV EPRS1 FRMD5 GSTM4 HDAC11 MTA1 NELFA NELFB PRMT5 SERF2 SMAD4 TXK UBE3A ZNF638
Entrez ID		773	51497
HPRD ID		03004	16096
Ensembl ID		ENSG00000141837	ENSG00000101158
Uniprot IDs		A0A087WW63 B5TYJ1 O00555 Q9NS89	H0UI80 Q8IXH7
PDB IDs		3BXK	5L3X 6GML
Enriched GO Terms of Interacting Partners?
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