ORMDL3 and RNF5

Data Source:
BioGRID (two hybrid)

		ORMDL3	RNF5
Description		ORMDL sphingolipid biosynthesis regulator 3	ring finger protein 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane SPOTS Complex Specific Granule Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein-containing Complex Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of B Cell Apoptotic Process Ceramide Metabolic Process Sphingomyelin Biosynthetic Process Regulation Of Smooth Muscle Contraction Positive Regulation Of Autophagy Myelination Neutrophil Degranulation Motor Behavior Cellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Serine C-palmitoyltransferase Activity	Ubiquitin-dependent Protein Catabolic Process Response To Bacterium Negative Regulation Of Autophagy Ubiquitin-dependent ERAD Pathway Protein Destabilization ERAD Pathway Cellular Protein Catabolic Process Transmembrane Transport Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination ER-associated Misfolded Protein Catabolic Process Endoplasmic Reticulum Mannose Trimming Regulation Of Autophagosome Assembly
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation	ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Adult asthma ( 30787307) Asthma ( 31959851 31619474 21150878 29273806 28461288 17611496 22561531) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Autoimmune traits (pleiotropy) ( 30572963) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 18587394 28067908 21102463) Hematological parameters ( 19820697) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 28425483 23000144 21399635 20639880) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Selective IgA deficiency ( 27723758) Systemic sclerosis ( 28314753) Systemising ( 31508503) Type 1 diabetes ( 30659077 21829393 25751624 19430480) Ulcerative colitis ( 28067908 20228799 21297633) White blood cell count ( 27863252 21738480)	Advanced glycation end-product levels ( 26083729) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908) Waist circumference ( 31453325) Waist circumference variance ( 31453325)
Interacting Genes		30 interacting genes: APP AQP6 ARL13B C10orf67 CERS3 COQ8A EBP EEF1A1 ELOVL4 ERGIC3 FAM209A GET1 GPR101 GPR152 HSD17B13 KCNK5 LEPROTL1 LMNA LNX1 MTIF3 PTPN11 REEP2 RETREG3 RNF5 ROM1 SLC10A1 SLC35C2 SLC7A1 SYT2 TMEM237	51 interacting genes: ABHD16A ARL6IP1 CFTR CYB561 CYB561A3 DGAT2L6 FAM241B FHOD1 GLP1R INSIG2 JKAMP LEPROTL1 MAVS MPDZ MS4A1 ORMDL3 PLP2 PLPP6 PRAF2 PXN RABAC1 RHBDD1 RNF185 RUSF1 SCD SEC22A SLC1A1 SLC38A7 TGFBR1 TMEM120B TMEM242 TNFAIP3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2K UBE2N UBE2U UBE2V1 UBE2W UBE2Z UBTD1 YIPF1 YIPF2 YIPF4
Entrez ID		94103	6048
HPRD ID		17803	04057
Ensembl ID		ENSG00000172057	ENSG00000204308
Uniprot IDs		A0A024R1W6 Q8N138	A0A024RCQ4 Q99942
PDB IDs
Enriched GO Terms of Interacting Partners?
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