TSNAX and NSMCE2

Data Source:
BioGRID (enzymatic study)

		TSNAX	NSMCE2
Description		translin associated factor X	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Perinuclear Region Of Cytoplasm	Chromosome, Telomeric Region Nucleus Nucleoplasm Nuclear Body PML Body Smc5-Smc6 Complex
	Molecular Function	DNA Binding RNA Binding Endoribonuclease Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding	Protein Binding Zinc Ion Binding SUMO Transferase Activity SUMO Ligase Activity
	Biological Process	Multicellular Organism Development Spermatogenesis Cell Differentiation Production Of SiRNA Involved In RNA Interference RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Protein Sumoylation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Cellular Senescence
Pathways		Small interfering RNA (siRNA) biogenesis	SUMOylation of DNA damage response and repair proteins
Drugs
Diseases
GWAS		Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Metabolite levels ( 23823483)	Amyotrophic lateral sclerosis ( 24931836) Amyotrophic lateral sclerosis or frontotemporal dementia ( 24931836) C-reactive protein levels ( 30388399) Diffusing capacity of carbon monoxide ( 30694715) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Fractures (paediatric) ( 32742401) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Pursuit maintenance gain ( 29064472) Response to statin therapy ( 20339536) Triglyceride levels ( 32203549) White blood cell count ( 32888494)
Interacting Genes		41 interacting genes: AIMP1 AKAP9 BEX3 BLOC1S5 C1D CARD9 CDK5RAP2 CEP68 CKAP4 COG6 EMILIN1 GADD45G GOLGA3 GPATCH2 GRIPAP1 HMGB2 KCNE4 KLC3 KRT31 LDB2 LDOC1 LZTS2 MRFAP1L1 NSMCE2 NTAQ1 PBXIP1 PMF1 PRPF18 RALYL RFC5 SOGA1 SPRED2 SUN1 SYCE2 SYT17 TCF12 TCP11L1 TSN TSNAXIP1 UBE2I VPS28	4 interacting genes: ETV1 TSNAX TXLNA USP28
Entrez ID		7257	286053
HPRD ID		04270	08131
Ensembl ID		ENSG00000116918	ENSG00000156831
Uniprot IDs		A0A024R3V8 Q99598	A0A024R9J6 E5RFJ1 Q96MF7
PDB IDs		3PJA 3QB5	2YU4
Enriched GO Terms of Interacting Partners?
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