NSMCE2 and TSNAX

Data Source:
BioGRID (enzymatic study)

		NSMCE2	TSNAX
Description		NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase	translin associated factor X
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Nuclear Body PML Body Smc5-Smc6 Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding SUMO Transferase Activity SUMO Ligase Activity	DNA Binding RNA Binding Endoribonuclease Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Protein Sumoylation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Cellular Senescence	Multicellular Organism Development Spermatogenesis Cell Differentiation Production Of SiRNA Involved In RNA Interference RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		SUMOylation of DNA damage response and repair proteins	Small interfering RNA (siRNA) biogenesis
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 24931836) Amyotrophic lateral sclerosis or frontotemporal dementia ( 24931836) C-reactive protein levels ( 30388399) Diffusing capacity of carbon monoxide ( 30694715) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Fractures (paediatric) ( 32742401) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Pursuit maintenance gain ( 29064472) Response to statin therapy ( 20339536) Triglyceride levels ( 32203549) White blood cell count ( 32888494)	Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: ETV1 TSNAX TXLNA USP28	41 interacting genes: AIMP1 AKAP9 BEX3 BLOC1S5 C1D CARD9 CDK5RAP2 CEP68 CKAP4 COG6 EMILIN1 GADD45G GOLGA3 GPATCH2 GRIPAP1 HMGB2 KCNE4 KLC3 KRT31 LDB2 LDOC1 LZTS2 MRFAP1L1 NSMCE2 NTAQ1 PBXIP1 PMF1 PRPF18 RALYL RFC5 SOGA1 SPRED2 SUN1 SYCE2 SYT17 TCF12 TCP11L1 TSN TSNAXIP1 UBE2I VPS28
Entrez ID		286053	7257
HPRD ID		08131	04270
Ensembl ID		ENSG00000156831	ENSG00000116918
Uniprot IDs		A0A024R9J6 E5RFJ1 Q96MF7	A0A024R3V8 Q99598
PDB IDs		2YU4	3PJA 3QB5
Enriched GO Terms of Interacting Partners?
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