NSMCE2 and ETV1

Data Source:
BioGRID (enzymatic study)

		NSMCE2	ETV1
Description		NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase	ETS variant transcription factor 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Nuclear Body PML Body Smc5-Smc6 Complex	Chromatin Nucleus
	Molecular Function	Protein Binding Zinc Ion Binding SUMO Transferase Activity SUMO Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Protein Sumoylation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Cellular Senescence	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Peripheral Nervous System Neuron Development
Pathways		SUMOylation of DNA damage response and repair proteins
Drugs
Diseases			Ewing's sarcoma Prostate cancer
GWAS		Amyotrophic lateral sclerosis ( 24931836) Amyotrophic lateral sclerosis or frontotemporal dementia ( 24931836) C-reactive protein levels ( 30388399) Diffusing capacity of carbon monoxide ( 30694715) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Fractures (paediatric) ( 32742401) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Pursuit maintenance gain ( 29064472) Response to statin therapy ( 20339536) Triglyceride levels ( 32203549) White blood cell count ( 32888494)	Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Coronary artery disease ( 29212778) Coronary atherosclerosis (time to event) ( 32589924) Height ( 28552196 31217584) Intraocular pressure ( 30591961) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317) Post bronchodilator percent predicted FEV1 in smoking ( 30068317) Renal underexcretion gout ( 32238385) Type 2 diabetes ( 24509480 32499647 30718926) Verbal declarative memory ( 25648963) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: ETV1 TSNAX TXLNA USP28	19 interacting genes: ATR CCND3 EP300 ERG JUN KAT2B KCNA2 MAPK14 MAPK3 MAPK8 MAPKAPK2 NCOA2 NCOA3 NSMCE2 PRKACA RPS6KA1 RPS6KA5 SPI1 UBE2I
Entrez ID		286053	2115
HPRD ID		08131	02765
Ensembl ID		ENSG00000156831	ENSG00000006468
Uniprot IDs		A0A024R9J6 E5RFJ1 Q96MF7	B5MCT2 B7Z2C9 P50549
PDB IDs		2YU4	4AVP 4BNC 5ILS
Enriched GO Terms of Interacting Partners?
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