TSNAX and RFC5

Data Source:
BioGRID (two hybrid)

		TSNAX	RFC5
Description		translin associated factor X	replication factor C subunit 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm DNA Replication Factor C Complex Ctf18 RFC-like Complex
	Molecular Function	DNA Binding RNA Binding Endoribonuclease Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding	DNA Clamp Loader Activity Protein Binding ATP Binding Single-stranded DNA Helicase Activity Enzyme Binding
	Biological Process	Multicellular Organism Development Spermatogenesis Cell Differentiation Production Of SiRNA Involved In RNA Interference RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	DNA Replication DNA-dependent DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication DNA Duplex Unwinding Nucleotide-excision Repair, DNA Incision Error-prone Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Error-free Translesion Synthesis Positive Regulation Of DNA-directed DNA Polymerase Activity Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Small interfering RNA (siRNA) biogenesis	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Metabolite levels ( 23823483)	Metabolite levels ( 23823483) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Physiological traits ( 31902109)
Interacting Genes		41 interacting genes: AIMP1 AKAP9 BEX3 BLOC1S5 C1D CARD9 CDK5RAP2 CEP68 CKAP4 COG6 EMILIN1 GADD45G GOLGA3 GPATCH2 GRIPAP1 HMGB2 KCNE4 KLC3 KRT31 LDB2 LDOC1 LZTS2 MRFAP1L1 NSMCE2 NTAQ1 PBXIP1 PMF1 PRPF18 RALYL RFC5 SOGA1 SPRED2 SUN1 SYCE2 SYT17 TCF12 TCP11L1 TSN TSNAXIP1 UBE2I VPS28	35 interacting genes: ARID5A BIRC2 CCNC CHTF18 COPS6 DAPK1 DDIT4L EEF1A1 EML2 EXOSC8 FAM166B KRT34 LMO3 LRIF1 MED31 N4BP3 NAB2 NR5A1 PCNA PPP1R16B PTEN RBM48 RFC2 RFC4 SUMO2 TASOR2 TRIM38 TSNAX UNC119 XAF1 XIAP YPEL3 ZMAT1 ZNF19 ZNF426
Entrez ID		7257	5985
HPRD ID		04270	02677
Ensembl ID		ENSG00000116918	ENSG00000111445
Uniprot IDs		A0A024R3V8 Q99598	P40937 Q59GW7
PDB IDs		3PJA 3QB5	1LFS 6VVO
Enriched GO Terms of Interacting Partners?
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