TRAF6 and MBP

Data Source:
HPRD (in vivo)

		TRAF6	MBP
Description		TNF receptor associated factor 6	myelin basic protein
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell Cortex Cytoplasmic Side Of Plasma Membrane Endosome Membrane Protein-containing Complex CD40 Receptor Complex Perinuclear Region Of Cytoplasm Plasma Membrane Signaling Receptor Complex	Nucleus Plasma Membrane Cell Surface Protein-containing Complex Internode Region Of Axon Neuronal Cell Body Myelin Sheath Compact Myelin Synapse Cell Periphery
	Molecular Function	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding Histone Deacetylase Binding Protein Kinase B Binding Protein N-terminus Binding Ubiquitin Protein Ligase Activity	Protease Binding Protein Binding Calmodulin Binding Structural Constituent Of Myelin Sheath
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Activation Of MAPK Activity Protein Polyubiquitination Ossification In Utero Embryonic Development Neural Tube Closure Stimulatory C-type Lectin Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To DNA Damage Stimulus I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity JNK Cascade Protein Deubiquitination Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Osteoclast Differentiation Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Protein Ubiquitination Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 9 Signaling Pathway Fc-epsilon Receptor Signaling Pathway T-helper 1 Type Immune Response Positive Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JUN Kinase Activity Bone Resorption Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Cell Development Positive Regulation Of Smooth Muscle Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Transcription Regulatory Region DNA Binding	MAPK Cascade Immune Response Chemical Synaptic Transmission Central Nervous System Development Sensory Perception Of Sound Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Positive Regulation Of Interleukin-6 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Myelination Membrane Organization Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Regulated proteolysis of p75NTR Downstream TCR signaling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Ub-specific processing proteases Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation MyD88 cascade initiated on plasma membrane	EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		Idiopathic inflammatory myopathy ( 26362759) Metabolite levels ( 23823483) Rheumatoid arthritis ( 30423114 24390342)	Age-related macular degeneration (geographic atrophy) ( 22705344) Blood osmolality (transformed sodium) ( 28360221) Depression in smokers ( 30219690) Erythrocyte cadmium concentration in never smokers ( 27005419) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Verbal declarative memory ( 25648963)
Interacting Genes		174 interacting genes: ABL1 APP ATM ATP6V1E1 ATXN3 BANK1 BCL3 BEX3 BMPR1B BRSK2 CALCOCO2 CASP8 CAV1 CBL CD40 CUL5 CYLD DLG4 DNA2 ECSIT EDA2R EDARADD FHL2 FYN GART GSK3B GTF2I H2AX H2BC21 HNRNPA1 HSD17B10 HSPA4 IL17RB IPMK IQUB IRAK1 IRAK2 IRAK3 IRAK4 IRF5 IRF7 IRF8 JAK2 KCNQ1 LIMD1 LNX1 MALT1 MAP2K1 MAP2K6 MAP2K7 MAP3K11 MAP3K14 MAP3K3 MAP3K5 MAP3K7 MAP3K8 MAPK14 MAPK8 MAPT MAST2 MATR3 MAVS MBP MCL1 MEOX2 MTOR MTURN NEAT1 NGFR NTRK1 NTRK2 NUMBL OTUB1 OTUB2 OTUD7B PEDS1-UBE2V1 PELI3 PFN1 PINK1 PLEKHF2 PLEKHO1 POLI PPP4C PRKCZ PSMB5 PSMC1 PSMC2 PSMC3 PSMD1 PSMD12 PSMD13 PSMD6 PSMD7 PTPN6 RAD23A RIPK2 RNF114 RNF31 RPL3 RPS2 RPS20 RPS27A SIGIRR SPHK1 SPOP SQSTM1 SRC STAMBP STK26 STRADB STUB1 SYK TAB1 TAB2 TAB3 TANK TAX1BP1 TDP2 TGFBR1 TICAM1 TICAM2 TIFA TIRAP TLR3 TNFAIP3 TNFRSF11A TNFRSF13B TNFRSF19 TNFSF11 TRAF1 TRAF2 TRAF3IP1 TRAF3IP2 TRAF4 TRAF5 TRAF7 TRAFD1 TRAM1 TRIM17 TRIM25 TRIM37 TXNIP UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2L3 UBE2N UBE2V1 UBOX5 UBTD1 UBXN7 UEVLD USP1 USP15 USP2 USP21 USP39 USP7 VPS52 XIAP YBX1 YES1 YOD1 YWHAQ ZBTB25 ZFAND5 ZMYND11 ZNF675 ZRANB1	81 interacting genes: ABL1 ADRB2 APTX ATN1 ATXN1 AURKA BMP2K CCR1 CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 CTDSPL DYRK1B HIPK2 HLA-DRA IKBKE ILK IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP2K1 MAP3K1 MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPK8 MAPKAPK5 MELK MICU2 MKNK1 MMP7 NEK9 PAK1 PDGFRL PKN1 PLEKHF2 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 PTAFR PTPRA RAF1 RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSSK6 ULK1
Entrez ID		7189	4155
HPRD ID		03833	01158
Ensembl ID		ENSG00000175104	ENSG00000197971
Uniprot IDs		Q9Y4K3	A0A024R384 P02686
PDB IDs		1LB4 1LB5 1LB6 2ECI 2JMD 3HCS 3HCT 3HCU 4Z8M 5ZUJ 6A33	1BX2 1FV1 1HQR 1K2D 1QCL 1YMM 1ZGL
Enriched GO Terms of Interacting Partners?
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