TNNI2 and PKD2L1

Data Source:
HPRD (in vivo)

		TNNI2	PKD2L1
Description		troponin I2, fast skeletal type	polycystin 2 like 1, transient receptor potential cation channel
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GO Annotations	Cellular Component	Nucleus Cytosol Troponin Complex	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Cytoplasmic Vesicle Calcium Channel Complex Intracellular Membrane-bounded Organelle Receptor Complex Ciliary Membrane Non-motile Cilium
	Molecular Function	Actin Binding Protein Binding Troponin T Binding	Calcium Activated Cation Channel Activity Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Cation Transmembrane Transporter Activity Calcium-activated Potassium Channel Activity Sour Taste Receptor Activity Identical Protein Binding Muscle Alpha-actinin Binding Alpha-actinin Binding
	Biological Process	Skeletal Muscle Contraction Muscle Contraction Regulation Of Muscle Contraction Muscle Filament Sliding Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Contraction	Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Cation Transport Smoothened Signaling Pathway Response To Water Sodium Ion Transmembrane Transport Detection Of Chemical Stimulus Involved In Sensory Perception Of Taste Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Protein Homotetramerization Calcium Ion Transmembrane Transport Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport
Pathways		Striated Muscle Contraction
Drugs
Diseases		Distal arthrogryposis (DA)
GWAS		Celiac disease ( 23936387) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Inflammatory bowel disease ( 23128233) Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Coronary artery disease ( 29212778 33020668) Diastolic blood pressure ( 30224653) Fatty acid desaturase activity (adipose tissue) ( 30453627) Glycerophospholipid levels ( 26068415) Heel bone mineral density ( 30598549 28869591) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte counts ( 32888494) Macular thickness ( 30535121) Mean platelet volume ( 32888494 27863252) Monocyte count ( 32888494) Obesity-related traits ( 23251661) Palmitic acid (16:0) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 28298293 23362303) Phospholipid levels (plasma) ( 22359512) Red cell distribution width ( 32888494) Refractive error ( 32231278) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Serum metabolite levels ( 24625756) Serum metabolite levels (CMS) ( 31636271) Serum metabolite ratios in chronic kidney disease ( 29545352) Squamous cell lung carcinoma ( 28604730) Vaccenic acid (18:1n-7) levels ( 28298293)
Interacting Genes		21 interacting genes: ACTB C1orf109 CALM1 CTNNA3 DCAF11 EFCAB2 ESRRA ESRRG HNF4G MNS1 NME7 PKD2L1 PSMC5 RORB TNNC1 TNNC2 TNNT1 TNNT3 TRIM55 TRIM63 UPF2	4 interacting genes: CLDN19 TNNI1 TNNI2 TNNI3
Entrez ID		7136	9033
HPRD ID		01843	16063
Ensembl ID		ENSG00000130598	ENSG00000107593
Uniprot IDs		P48788	Q1L4F0 Q9P0L9
PDB IDs		2MKP	3TE3 4GIF 6DU8
Enriched GO Terms of Interacting Partners?
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