CLDN5 and SLC35B4

Data Source:
BioGRID (two hybrid)

		CLDN5	SLC35B4
Description		claudin 5	solute carrier family 35 member B4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Apicolateral Plasma Membrane Cell Junction Cortical Actin Cytoskeleton Tight Junction	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Integral Component Of Golgi Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	UDP-N-acetylglucosamine Transmembrane Transporter Activity UDP-xylose Transmembrane Transporter Activity Protein Binding Transmembrane Transporter Activity
	Biological Process	Outflow Tract Morphogenesis Cell-cell Junction Assembly Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Learning Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Positive Regulation Of Protein Binding Maintenance Of Blood-brain Barrier Negative Regulation Of Vascular Permeability Roof Of Mouth Development Face Morphogenesis Bicellular Tight Junction Assembly Tight Junction Assembly Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Bicellular Tight Junction Assembly Establishment Of Blood-retinal Barrier Regulation Of Bicellular Tight Junction Assembly	Regulation Of Gluconeogenesis Carbohydrate Transport UDP-xylose Transmembrane Transport UDP-N-acetylglucosamine Transmembrane Transport
Pathways		Tight junction interactions RUNX1 regulates expression of components of tight junctions	Transport of nucleotide sugars
Drugs
Diseases
GWAS			Mean platelet volume ( 32888494 27863252) Plateletcrit ( 32888494) Systolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133)
Interacting Genes		40 interacting genes: AQP1 BTNL8 CCDC167 CLDN3 CLRN2 CNPY3 CORIN CTRL CXCL9 CYB561A3 EFNA5 EHHADH ERG28 ERMP1 FXYD6-FXYD2 GYPA LAT LHFPL5 MIP MPDZ PLP2 PLPPR2 PMP22 RPRM SFTPC SGCG SLC35B4 SMIM3 TECR TF TJP1 TMEM128 TMEM140 TMEM14C TMEM182 TMEM190 TMEM222 TSPAN2 VAMP5 YIPF1	32 interacting genes: AQP6 CD79A CISD2 CLDN5 CPLX4 CREB3L1 EBAG9 ERGIC3 ERP29 FAM209A FAM210B FFAR2 GPR152 GPX8 HSD17B13 KASH5 LHFPL5 LMNA MMGT1 MUC1 PDZK1IP1 PVR RHBDL2 SCARA5 SLC18A1 STOM TBXA2R TMEM130 TMEM237 TMEM52B TYROBP VSIR
Entrez ID		7122	84912
HPRD ID		03654	11578
Ensembl ID		ENSG00000184113	ENSG00000205060
Uniprot IDs		D3DX19 O00501	Q969S0
PDB IDs
Enriched GO Terms of Interacting Partners?
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