CLDN5 and TMEM190

Data Source:
BioGRID (two hybrid)

		CLDN5	TMEM190
Description		claudin 5	transmembrane protein 190
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Apicolateral Plasma Membrane Cell Junction Cortical Actin Cytoskeleton Tight Junction	Inner Acrosomal Membrane Nucleus Integral Component Of Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Protein Binding Protein Self-association
	Biological Process	Outflow Tract Morphogenesis Cell-cell Junction Assembly Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Learning Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Positive Regulation Of Protein Binding Maintenance Of Blood-brain Barrier Negative Regulation Of Vascular Permeability Roof Of Mouth Development Face Morphogenesis Bicellular Tight Junction Assembly Tight Junction Assembly Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Bicellular Tight Junction Assembly Establishment Of Blood-retinal Barrier Regulation Of Bicellular Tight Junction Assembly	Hematopoietic Progenitor Cell Differentiation
Pathways		Tight junction interactions RUNX1 regulates expression of components of tight junctions
Drugs
Diseases
GWAS			Blood protein levels ( 30072576 29875488)
Interacting Genes		40 interacting genes: AQP1 BTNL8 CCDC167 CLDN3 CLRN2 CNPY3 CORIN CTRL CXCL9 CYB561A3 EFNA5 EHHADH ERG28 ERMP1 FXYD6-FXYD2 GYPA LAT LHFPL5 MIP MPDZ PLP2 PLPPR2 PMP22 RPRM SFTPC SGCG SLC35B4 SMIM3 TECR TF TJP1 TMEM128 TMEM140 TMEM14C TMEM182 TMEM190 TMEM222 TSPAN2 VAMP5 YIPF1	12 interacting genes: ARL13B CD69 CLDN5 CLEC2D KRTAP2-4 KRTAP5-11 KRTAP9-2 LDLRAD1 MACO1 MOB1A SPINT1 TEX29
Entrez ID		7122	147744
HPRD ID		03654	14373
Ensembl ID		ENSG00000184113	ENSG00000160472
Uniprot IDs		D3DX19 O00501	Q8WZ59
PDB IDs
Enriched GO Terms of Interacting Partners?
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