CLDN5 and CLDN3

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CLDN5	CLDN3
Description		claudin 5	claudin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Apicolateral Plasma Membrane Cell Junction Cortical Actin Cytoskeleton Tight Junction	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Protein-containing Complex Apical Junction Complex Tight Junction
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Transmembrane Signaling Receptor Activity Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Outflow Tract Morphogenesis Cell-cell Junction Assembly Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Learning Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Positive Regulation Of Protein Binding Maintenance Of Blood-brain Barrier Negative Regulation Of Vascular Permeability Roof Of Mouth Development Face Morphogenesis Bicellular Tight Junction Assembly Tight Junction Assembly Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Bicellular Tight Junction Assembly Establishment Of Blood-retinal Barrier Regulation Of Bicellular Tight Junction Assembly	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Epithelial Cell Morphogenesis Cell Adhesion Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Establishment Of Endothelial Blood-brain Barrier Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Cell Junction Maintenance Maintenance Of Blood-brain Barrier Response To Ethanol Negative Regulation Of Wound Healing Bicellular Tight Junction Assembly Positive Regulation Of Wound Healing Regulation Of Membrane Permeability Regulation Of Transepithelial Transport Positive Regulation Of Cell Junction Assembly Positive Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Metallopeptidase Activity
Pathways		Tight junction interactions RUNX1 regulates expression of components of tight junctions	Tight junction interactions
Drugs
Diseases
GWAS			Mean platelet volume ( 27863252) Platelet distribution width ( 27863252)
Interacting Genes		40 interacting genes: AQP1 BTNL8 CCDC167 CLDN3 CLRN2 CNPY3 CORIN CTRL CXCL9 CYB561A3 EFNA5 EHHADH ERG28 ERMP1 FXYD6-FXYD2 GYPA LAT LHFPL5 MIP MPDZ PLP2 PLPPR2 PMP22 RPRM SFTPC SGCG SLC35B4 SMIM3 TECR TF TJP1 TMEM128 TMEM140 TMEM14C TMEM182 TMEM190 TMEM222 TSPAN2 VAMP5 YIPF1	7 interacting genes: APP CLDN1 CLDN5 POM121 PRKACA TJP1 WNK4
Entrez ID		7122	1365
HPRD ID		03654	04219
Ensembl ID		ENSG00000184113	ENSG00000165215
Uniprot IDs		D3DX19 O00501	O15551 Q75L79
PDB IDs
Enriched GO Terms of Interacting Partners?
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