CLDN3 and WNK4

Data Source:
HPRD (in vivo)

		CLDN3	WNK4
Description		claudin 3	WNK lysine deficient protein kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Protein-containing Complex Apical Junction Complex Tight Junction	Cytoplasm Cytosol Bicellular Tight Junction Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Structural Molecule Activity Protein Binding Identical Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Epithelial Cell Morphogenesis Cell Adhesion Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Establishment Of Endothelial Blood-brain Barrier Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Cell Junction Maintenance Maintenance Of Blood-brain Barrier Response To Ethanol Negative Regulation Of Wound Healing Bicellular Tight Junction Assembly Positive Regulation Of Wound Healing Regulation Of Membrane Permeability Regulation Of Transepithelial Transport Positive Regulation Of Cell Junction Assembly Positive Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Metallopeptidase Activity	Protein Phosphorylation Ion Transport Chloride Transport Protein Localization Negative Regulation Of Sodium Ion Transport Intracellular Signal Transduction Regulation Of Cellular Process Ion Homeostasis Renal Sodium Ion Absorption Distal Tubule Morphogenesis Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Tight junction interactions	Stimuli-sensing channels
Drugs
Diseases			Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Mean platelet volume ( 27863252) Platelet distribution width ( 27863252)
Interacting Genes		7 interacting genes: APP CLDN1 CLDN5 POM121 PRKACA TJP1 WNK4	11 interacting genes: AKT1 BCL6 CLDN1 CLDN2 CLDN3 CLDN4 KLHL2 KLHL3 NEDD4L SLC12A3 STK39
Entrez ID		1365	65266
HPRD ID		04219	03505
Ensembl ID		ENSG00000165215	ENSG00000126562
Uniprot IDs		O15551 Q75L79	Q96J92
PDB IDs			2V3S 4CH9 4CHB
Enriched GO Terms of Interacting Partners?
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