THPO and NUMBL

Data Source:
BioGRID (two hybrid)

		THPO	NUMBL
Description		thrombopoietin	NUMB like endocytic adaptor protein
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm
	Molecular Function	Signaling Receptor Binding Cytokine Activity Hormone Activity Growth Factor Activity	Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Multicellular Organism Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Megakaryocyte Development Thrombopoietin-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Receptor Signaling Pathway Via STAT Positive Regulation Of Hematopoietic Stem Cell Proliferation	Nervous System Development Axonogenesis Cytokine-mediated Signaling Pathway Protein Metabolic Process Lateral Ventricle Development Neuroblast Division In Subventricular Zone Adherens Junction Organization Positive Regulation Of Neurogenesis
Pathways		Platelet Aggregation (Plug Formation)
Drugs
Diseases
GWAS		Cardiometabolic and hematological traits ( 27668658) Diisocyanate-induced asthma ( 25918132) Mean spheric corpuscular volume ( 32888494) Platelet count ( 22139419 29403010 32888494 20139978 27863252) Plateletcrit ( 32888494 27863252)	Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941) Carotid intima media thickness (mean) ( 31801372) Kawasaki disease ( 22446962) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730)
Interacting Genes		4 interacting genes: APH1A EP300 MPL NUMBL	23 interacting genes: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 YWHAG
Entrez ID		7066	9253
HPRD ID		02500	04931
Ensembl ID		ENSG00000090534	ENSG00000105245
Uniprot IDs		A0A3B3ITS0 F8W6L1 P40225 Q5FBX8	A0A0C4DGH3 A8K033 B7Z5W0 Q9Y6R0
PDB IDs		1V7M 1V7N	3F0W
Enriched GO Terms of Interacting Partners?
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