NUMBL and NOTCH1

  • Data Source:
  • HPRD (in vitro, two hybrid)

NUMBL

NOTCH1

Description NUMB like endocytic adaptor protein notch receptor 1
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941)
  • Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941)
  • Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941)
  • Carotid intima media thickness (mean) ( 31801372)
  • Kawasaki disease ( 22446962)
  • Lung adenocarcinoma ( 28604730)
  • Lung cancer ( 28604730)
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444)
  • Crohn's disease ( 28067908)
  • Eosinophil counts ( 32888494)
  • Inflammatory bowel disease ( 28067908)
  • Length of menstrual cycle ( 26732621)
  • Mean corpuscular hemoglobin ( 32888494)
  • Red cell distribution width ( 28957414)
  • Triglyceride levels ( 32203549)
  • Ulcerative colitis ( 28067908)
Interacting Genes 23 interacting genes: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 YWHAG 81 interacting genes: ADAM17 AKT1 APBA1 ARL6IP5 B3GALT4 BLOC1S1 CACNA1A CAMK4 CASR CBL CCN3 CEP57L1 CNTN1 COL4A6 CTNNB1 DAZAP2 DLL1 DLL4 DTX1 DTX2 EGFL7 EP300 EXT1 FAM185A FBXW7 FURIN GFI1B GOLGA2 GOPC GSK3B HMGN5 ILK ITCH JAG1 JAG2 KAT2A KAT2B KIAA1191 LCK LEF1 LFNG LINC00260 LINC02907 LNX2 MAGEA1 MAGED1 MAML1 MAML2 MAML3 MAP3K1 MDM2 MEF2C MFNG NFKB1 NUMB NUMBL PIK3CG POFUT1 POU2AF1 PRKCD PSEN1 PSEN2 RBP3 RBPJ REL RELA RHOA RUNX3 SMAD3 SNAI1 SNW1 TLE3 USP10 USP12 USP2 USP7 WDR12 WWP1 XIAP XRCC6 YY1
Entrez ID 9253 4851
HPRD ID 04931 01827
Ensembl ID ENSG00000105245 ENSG00000148400
Uniprot IDs A0A0C4DGH3 A8K033 B7Z5W0 Q9Y6R0 P46531
PDB IDs 3F0W 1PB5 1TOZ 1YYH 2F8X 2F8Y 2HE0 2VJ3 3ETO 3I08 3L95 3NBN 3V79 4CUD 4CUE 4CUF 4D0E 4D0F 5FM9 5FMA 5KZO 5L0R 5UB5 6IDF 6PY8
Enriched GO Terms of Interacting Partners?
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