THPO and MPL

Data Source:
HPRD (in vivo)

		THPO	MPL
Description		thrombopoietin	MPL proto-oncogene, thrombopoietin receptor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Golgi Apparatus Plasma Membrane Cell Surface Integral Component Of Membrane Nuclear Membrane Neuron Projection Neuronal Cell Body
	Molecular Function	Signaling Receptor Binding Cytokine Activity Hormone Activity Growth Factor Activity	Protein Binding Thrombopoietin Receptor Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Multicellular Organism Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Megakaryocyte Development Thrombopoietin-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Receptor Signaling Pathway Via STAT Positive Regulation Of Hematopoietic Stem Cell Proliferation	Neutrophil Homeostasis Monocyte Homeostasis Thrombopoietin-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Platelet Aggregation Cellular Response To Hypoxia Positive Regulation Of Platelet Formation Eosinophil Homeostasis Basophil Homeostasis
Pathways		Platelet Aggregation (Plug Formation)	Platelet Aggregation (Plug Formation)
Drugs			Romiplostim SB-559448 Eltrombopag Thrombopoietin Avatrombopag Lusutrombopag
Diseases			Congenital amegakaryocytic thrombocytopenia (CAMT)
GWAS		Cardiometabolic and hematological traits ( 27668658) Diisocyanate-induced asthma ( 25918132) Mean spheric corpuscular volume ( 32888494) Platelet count ( 22139419 29403010 32888494 20139978 27863252) Plateletcrit ( 32888494 27863252)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Platelet count ( 32888494) Plateletcrit ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: APH1A EP300 MPL NUMBL	9 interacting genes: ANKRA2 ATXN2L IRS2 JAK2 PTPN11 SHC1 SOCS1 THPO YWHAQ
Entrez ID		7066	4352
HPRD ID		02500	01161
Ensembl ID		ENSG00000090534	ENSG00000117400
Uniprot IDs		A0A3B3ITS0 F8W6L1 P40225 Q5FBX8	P40238
PDB IDs		1V7M 1V7N
Enriched GO Terms of Interacting Partners?
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