NUMBL and SPSB3

Data Source:
BioGRID (two hybrid, two hybrid)

		NUMBL	SPSB3
Description		NUMB like endocytic adaptor protein	splA/ryanodine receptor domain and SOCS box containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Nervous System Development Axonogenesis Cytokine-mediated Signaling Pathway Protein Metabolic Process Lateral Ventricle Development Neuroblast Division In Subventricular Zone Adherens Junction Organization Positive Regulation Of Neurogenesis	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification
Pathways			Neddylation
Drugs
Diseases
GWAS		Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941) Carotid intima media thickness (mean) ( 31801372) Kawasaki disease ( 22446962) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730)	Appendicular lean mass ( 33097823) Plateletcrit ( 32888494) PR interval ( 32439900)
Interacting Genes		23 interacting genes: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 YWHAG	5 interacting genes: CSNK2B ENKD1 MAPK8IP2 NUMBL ZNF396
Entrez ID		9253	90864
HPRD ID		04931	18107
Ensembl ID		ENSG00000105245	ENSG00000162032
Uniprot IDs		A0A0C4DGH3 A8K033 B7Z5W0 Q9Y6R0	Q6PJ21
PDB IDs		3F0W
Enriched GO Terms of Interacting Partners?
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