TAC3 and UBR1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TAC3	UBR1
Description		tachykinin precursor 3	ubiquitin protein ligase E3 component n-recognin 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol
	Molecular Function	Signaling Receptor Binding Protein Binding	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Positive Regulation Of Blood Pressure	Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Pathways		Tachykinin receptors bind tachykinins G alpha (q) signalling events	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Copper
Diseases		Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)	Johanson-Blizzard syndrome
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Menopause (age at onset) ( 26414677) Red cell distribution width ( 28957414) Schizophrenia ( 25056061)	MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)
Interacting Genes		12 interacting genes: CCDC90B ELP1 FEZ1 GPRASP1 PRB1 PRH1 PTN TACR1 TACR2 TACR3 UBC UBR1	28 interacting genes: ANXA3 ARL15 ARL3 ARL4D BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NTAN1 NTAQ1 NUDT3 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2
Entrez ID		6866	197131
HPRD ID		08877	09342
Ensembl ID		ENSG00000166863	ENSG00000159459
Uniprot IDs		A0A024RB47 A0A024RB97 Q9UHF0	Q8IWV7
PDB IDs		1P9F	3NY1 5TDC
Enriched GO Terms of Interacting Partners?
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