ST14 and SPINT1

Data Source:
HPRD (in vivo, in vitro)

		ST14	SPINT1
Description		ST14 transmembrane serine protease matriptase	serine peptidase inhibitor, Kunitz type 1
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Neural Tube Closure Proteolysis Keratinocyte Differentiation Epithelial Cell Morphogenesis Involved In Placental Branching Cornification	Neural Tube Closure Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Positive Regulation Of Glial Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Cellular Response To BMP Stimulus Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Formation of the cornified envelope Formation of the cornified envelope	MET Receptor Activation Signaling by MST1
Drugs		Urokinase Benzamidine Camostat
Diseases		Ichthyosis with hypotrichosis
GWAS		Adverse response to drug ( 30420678) Pre-treatment viral load in HIV-1 infection ( 31219150)	Blood protein levels ( 30072576) Malaria ( 31844061) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		17 interacting genes: AKT1 APC CASP8 CDCP1 CDKN2C CHEK2 F2RL1 HGF NOTCH2 PDGFC PHB PLAU RAD51 RGS16 SPINT1 STK11 TGFB1	23 interacting genes: ADAM33 AGR3 CLDN11 CLEC7A FAM3C HGFAC HMGB1 KRTAP1-3 MAL NLGN3 SLC38A7 SMCO4 ST14 TENT5A TF TMEM109 TMEM190 TMEM97 TSPAN33 UBQLN2 UBQLN4 UPK1B VAMP5
Entrez ID		6768	6692
HPRD ID		06005	05494
Ensembl ID		ENSG00000149418	ENSG00000166145
Uniprot IDs		Q9Y5Y6	O43278
PDB IDs		1EAW 1EAX 2FMV 2GV6 2GV7 3BN9 3NCL 3NPS 3P8F 3P8G 3SO3 4IS5 4ISL 4ISN 4ISO 4JYT 4JZ1 4JZI 4O97 4O9V 4R0I 5LYO 6N4T	1YC0 2MSX 4ISL 4ISN 4ISO 5EZD 5H7V
Enriched GO Terms of Interacting Partners?
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