SRY and SLC9A3R2

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SRY	SLC9A3R2
Description		sex determining region Y	SLC9A3 regulator 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Apical Plasma Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Calmodulin Binding Transcription Factor Binding	Signaling Receptor Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Sex Differentiation Anatomical Structure Morphogenesis Positive Regulation Of Gene Expression Cell Differentiation Male Sex Determination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Male Gonad Development	Protein-containing Complex Assembly Protein Localization To Plasma Membrane
Pathways		Deactivation of the beta-catenin transactivating complex Transcriptional regulation of testis differentiation
Drugs
Diseases		46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS			Diastolic blood pressure ( 27841878 30578418) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		7 interacting genes: AR EP300 HDAC3 KPNB1 SLC9A3R2 SMAD3 ZNF208	41 interacting genes: ABCC4 ACTN4 ADORA2B ADRB2 ATP2B2 CFTR DLGAP4 EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAZ TBC1D10A TRAF4 WWP2 WWTR1
Entrez ID		6736	9351
HPRD ID		08364	05946
Ensembl ID		ENSG00000184895	ENSG00000065054
Uniprot IDs		A7WPU8 Q05066	Q15599
PDB IDs		1HRY 1HRZ 1J46 1J47 2GZK 6EDB	2D11 2HE4 2OCS 4P0C
Enriched GO Terms of Interacting Partners?
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