SLC9A3R2 and SLC22A5

Data Source:
HPRD (two hybrid)

		SLC9A3R2	SLC22A5
Description		SLC9A3 regulator 2	solute carrier family 22 member 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Apical Plasma Membrane Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding	Protein Binding ATP Binding Carnitine Transmembrane Transporter Activity Symporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity PDZ Domain Binding Xenobiotic Transmembrane Transporter Activity (R)-carnitine Transmembrane Transporter Activity
	Biological Process	Protein-containing Complex Assembly Protein Localization To Plasma Membrane	Sodium Ion Transport Response To Symbiotic Bacterium Quaternary Ammonium Group Transport Carnitine Transport Positive Regulation Of Intestinal Epithelial Structure Maintenance Sodium-dependent Organic Cation Transport Transport Across Blood-brain Barrier (R)-carnitine Transmembrane Transport Carnitine Transmembrane Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways			Carnitine metabolism Organic cation transport Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)
Drugs			Levocarnitine
Diseases			Crohn's disease Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS		Diastolic blood pressure ( 27841878 30578418) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Systolic blood pressure ( 27841878 30578418)	Acylcarnitine levels ( 26068415) Asthma ( 31959851 20860503 31619474 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Carotid plaque maximum area ( 32469969) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Diastolic blood pressure ( 30578418) Fibrinogen ( 20031577) Height ( 20881960) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Intracranial aneurysm ( 33199917) Low density lipoprotein cholesterol levels ( 29083408 32154731) Maximum stenosis ( 32469969) Mean area of carotid plaque ( 32469969) Mean degree of stenosis ( 32469969) Mean platelet volume ( 32888494) Mosquito bite size ( 28199695) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Serum metabolite levels ( 23093944) Subcortical volume (MOSTest) ( 32665545) Sum of carotid plaque area ( 32469969) Ulcerative colitis ( 28067908) White blood cell count ( 32888494)
Interacting Genes		41 interacting genes: ABCC4 ACTN4 ADORA2B ADRB2 ATP2B2 CFTR DLGAP4 EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAZ TBC1D10A TRAF4 WWP2 WWTR1	11 interacting genes: KRT27 KRT34 KRTAP6-3 MTUS2 NBPF19 NOTCH2NLA PDZD3 PDZK1 SH3RF1 SLC9A3R1 SLC9A3R2
Entrez ID		9351	6584
HPRD ID		05946	04539
Ensembl ID		ENSG00000065054	ENSG00000197375
Uniprot IDs		Q15599	O76082
PDB IDs		2D11 2HE4 2OCS 4P0C
Enriched GO Terms of Interacting Partners?
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