SRY and KAT8

Data Source:
BioGRID (affinity chromatography technology)

		SRY	KAT8
Description		sex determining region Y	lysine acetyltransferase 8
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Histone Acetyltransferase Complex Kinetochore Nucleus Nucleoplasm Nuclear Matrix MLL1 Complex MSL Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Calmodulin Binding Transcription Factor Binding	Transcription Coregulator Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Acetyltransferase Activity Enzyme Binding Methylated Histone Binding Histone Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Metal Ion Binding Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Sex Differentiation Anatomical Structure Morphogenesis Positive Regulation Of Gene Expression Cell Differentiation Male Sex Determination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Male Gonad Development	Regulation Of Autophagy Histone Acetylation Myeloid Cell Differentiation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Deactivation of the beta-catenin transactivating complex Transcriptional regulation of testis differentiation	HATs acetylate histones
Drugs
Diseases		46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS			Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 25673413) Family history of Alzheimer's disease ( 30617256) Parkinson's disease ( 28892059) Triglyceride levels ( 32154731)
Interacting Genes		7 interacting genes: AR EP300 HDAC3 KPNB1 SLC9A3R2 SMAD3 ZNF208	12 interacting genes: ATM BAZ2A FOXP3 H4C1 KANSL1 KMT2A MSL3 PAF1 PLAU RNF2 TP53 TP53BP1
Entrez ID		6736	84148
HPRD ID		08364	11381
Ensembl ID		ENSG00000184895	ENSG00000103510
Uniprot IDs		A7WPU8 Q05066	Q9H7Z6
PDB IDs		1HRY 1HRZ 1J46 1J47 2GZK 6EDB	2GIV 2PQ8 2Y0M 3QAH 3TOA 3TOB 4DNC 5H43 5J8C 5J8F 5WCI 6BA2 6BA4 6CT2 6OIN 6OIO 6OIP 6OIQ 6OIR 6OWH 6OWI 6PD8 6PD9 6PDA 6PDB 6PDC 6PDD 6PDE 6PDF 6PDG 7CMR
Enriched GO Terms of Interacting Partners?
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