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KAT8 and H4C1
Data Source:
BioGRID
(enzymatic study, affinity chromatography technology)
KAT8
H4C1
Description
lysine acetyltransferase 8
H4 clustered histone 1
Image
GO Annotations
Cellular Component
Histone Acetyltransferase Complex
Kinetochore
Nucleus
Nucleoplasm
Nuclear Matrix
MLL1 Complex
MSL Complex
Nuclear Chromosome
Chromosome, Telomeric Region
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein-containing Complex
Extracellular Exosome
Molecular Function
Transcription Coregulator Activity
Histone Acetyltransferase Activity
Protein Binding
Transcription Factor Binding
Acetyltransferase Activity
Enzyme Binding
Methylated Histone Binding
Histone Binding
Histone Acetyltransferase Activity (H4-K5 Specific)
Histone Acetyltransferase Activity (H4-K8 Specific)
Metal Ion Binding
Histone Acetyltransferase Activity (H4-K16 Specific)
DNA Binding
RNA Binding
Protein Binding
Protein Domain Specific Binding
Protein Heterodimerization Activity
Biological Process
Regulation Of Autophagy
Histone Acetylation
Myeloid Cell Differentiation
Histone H4-K5 Acetylation
Histone H4-K8 Acetylation
Histone H4-K16 Acetylation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
RDNA Heterochromatin Assembly
Double-strand Break Repair Via Nonhomologous End Joining
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
DNA-templated Transcription, Initiation
Telomere Capping
Telomere Organization
CENP-A Containing Nucleosome Assembly
Cellular Protein Metabolic Process
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of Gene Silencing By MiRNA
Pathways
HATs acetylate histones
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
PKMTs methylate histone lysines
HDMs demethylate histones
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Drugs
Diseases
GWAS
Alzheimer's disease or family history of Alzheimer's disease (
30617256
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Body mass index (
25673413
)
Family history of Alzheimer's disease (
30617256
)
Parkinson's disease (
28892059
)
Triglyceride levels (
32154731
)
Interacting Genes
12 interacting genes:
ATM
BAZ2A
FOXP3
H4C1
KANSL1
KMT2A
MSL3
PAF1
PLAU
RNF2
TP53
TP53BP1
75 interacting genes:
ANP32A
ANP32B
ASF1A
BAZ2A
CBX3
CDK1
CDK2
COPS2
CREBBP
DPF2
DYRK1A
EID1
ELP3
EP300
ERCC6
FANCD2
GATAD2A
GATAD2B
H2AC20
HAT1
HDAC3
HDAC8
HIRIP3
HJURP
JADE1
JMJD6
KAT14
KAT2B
KAT5
KAT6A
KAT7
KAT8
KDM4A
KMT2C
KMT2D
KMT5B
KMT5C
L3MBTL2
MBTD1
MSL2
MSL3
MYB
NAP1L1
NCOR1
NCOR2
NSD1
NSD3
PAK1
PALB2
PARP10
PBRM1
PELP1
PHF1
PHF20
PHF8
PRMT5
PRMT7
PRMT8
PTMA
SETD7
SIRT7
TAF1A
TAF1B
TBL1X
THAP7
TLE3
TRIM29
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E3
UCHL5
WBP2
Entrez ID
84148
8359
HPRD ID
11381
04157
Ensembl ID
ENSG00000103510
ENSG00000278637
Uniprot IDs
Q9H7Z6
B2R4R0
P62805
PDB IDs
2GIV
2PQ8
2Y0M
3QAH
3TOA
3TOB
4DNC
5H43
5J8C
5J8F
5WCI
6BA2
6BA4
6CT2
6OIN
6OIO
6OIP
6OIQ
6OIR
6OWH
6OWI
6PD8
6PD9
6PDA
6PDB
6PDC
6PDD
6PDE
6PDF
6PDG
7CMR
1ZKK
2BQZ
2CV5
2IG0
2KWN
2KWO
2LVM
2QQS
2RJE
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3IJ1
3JPX
3NQJ
3NQU
3O36
3QBY
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
3WA9
3WAA
3WKJ
3WTP
3X1S
3X1T
3X1U
3X1V
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
4M38
4N3W
4N4F
4QUT
4QUU
4QYD
4U9W
4YM5
4YM6
4YY6
4YYD
4YYG
4YYH
4YYI
4YYJ
4YYK
4YYM
4YYN
4Z2M
4Z5T
5AV5
5AV6
5AV8
5AV9
5AVB
5AVC
5AY8
5B0Y
5B0Z
5B24
5B2I
5B2J
5B31
5B32
5B33
5B40
5BNV
5BNX
5BO0
5C3I
5CPI
5CPJ
5CPK
5FA5
5FFW
5FWE
5GSE
5GSU
5GT0
5GT3
5GTC
5GXQ
5JA4
5JRG
5KDM
5TEG
5X7X
5XF3
5XF4
5XF5
5Y0C
5Y0D
5YE3
5YE4
5Z23
5Z30
5ZBX
5ZGC
6A5L
6A5O
6A5P
6A5R
6A5T
6A5U
6ACP
6BUZ
6C0W
6E0C
6E0P
6FML
6HKT
6HTS
6INQ
6IR9
6J4W
6J4X
6J4Y
6J4Z
6J50
6J51
6JOU
6JR0
6JR1
6K1I
6K1J
6K1K
6KE9
6KVD
6KXV
6L49
6L4A
6L9H
6LA8
6LA9
6LE9
6M3V
6M44
6M4D
6M4G
6M4H
6MLC
6MUO
6MUP
6O1D
6R0C
6R8Y
6R8Z
6R90
6R91
6R92
6R93
6R94
6RNY
6RXS
6SE0
6SE6
6SEE
6SEF
6SEG
6T79
6T7A
6T7B
6T7C
6T7D
6T90
6T93
6UPK
6UPL
6USJ
6V92
6VO5
6X59
6X5A
6XJD
6Y5D
6YOV
7A08
7C0M
7JO9
7JOA
Enriched GO Terms of Interacting Partners
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