PRRX1 and SOX10

Data Source:
HPRD (two hybrid)

		PRRX1	SOX10
Description		paired related homeobox 1	SRY-box transcription factor 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Chromatin Nucleus Nucleoplasm Extrinsic Component Of Mitochondrial Outer Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding HMG Box Domain Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Identical Protein Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Transcription By RNA Polymerase II Embryonic Limb Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Determination Embryonic Cranial Skeleton Morphogenesis Artery Morphogenesis Cartilage Development Roof Of Mouth Development Regulation Of Neuron Projection Regeneration Neuronal Stem Cell Population Maintenance Positive Regulation Of DNA Repair By Transcription From RNA Polymerase II Promoter	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Neural Crest Cell Migration Morphogenesis Of An Epithelium Positive Regulation Of Neuroblast Proliferation Regulation Of Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Peripheral Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Schwann Cell Proliferation Oligodendrocyte Development Positive Regulation Of Gliogenesis Central Nervous System Myelination Melanocyte Differentiation Positive Regulation Of Myelination Lacrimal Gland Development Cellular Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Enteric Nervous System Development Digestive Tract Morphogenesis Developmental Growth Oligodendrocyte Differentiation Morphogenesis Of A Branching Epithelium Cellular Response To Progesterone Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases			46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis Waardenburg syndrome (WS)
GWAS		Atrial fibrillation ( 28416818 28416822 29290336 29892015 22544366) Blood protein levels ( 29875488) Calcific aortic valve stenosis ( 32141789) Central corneal thickness ( 32528159) Early onset atrial fibrillation ( 28460022) Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Hip circumference adjusted for BMI ( 28552196 25673412) Intraocular pressure ( 29617998) Ischemic stroke (cardioembolic) ( 29531354) Macular thickness ( 30535121) Male-pattern baldness ( 29146897 28196072) PR interval ( 32439900) Prevalent atrial fibrillation ( 28416818) Refractive error ( 32231278) Response to angiotensin II receptor blocker therapy ( 22566498) Systemic lupus erythematosus ( 33536424) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Mean spheric corpuscular volume ( 32888494)
Interacting Genes		8 interacting genes: CINP GTF2I MAFF MAFG SAAL1 SOX10 SRF SUOX	35 interacting genes: ALX4 C10orf55 CDK6 CEBPA CRX DAZAP2 DLX5 EGR2 EXOC5 GSK3B HHEX HIVEP1 HOXA3 HOXC4 HSF4 JUN MAGED1 MEOX1 NMI OLIG2 PAX3 PAX6 POU3F2 POU3F3 POU5F1 POU6F2 PRRX1 PRRX2 SP1 SUMO1 SUMO2 SUMO3 TCF12 UBE2I UTF1
Entrez ID		5396	6663
HPRD ID		01337	03752
Ensembl ID		ENSG00000116132	ENSG00000100146
Uniprot IDs		P54821	A0A024R1N6 P56693
PDB IDs
Enriched GO Terms of Interacting Partners?
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