SOX4 and NF1

Data Source:
BioGRID (fluorescent resonance energy transfer)

		SOX4	NF1
Description		SRY-box transcription factor 4	neurofibromin 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion	Nucleus Nucleolus Cytoplasm Cytosol Membrane Axon Dendrite
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific Double-stranded DNA Binding	GTPase Activator Activity Protein Binding Phosphatidylethanolamine Binding Phosphatidylcholine Binding
	Biological Process	Skeletal System Development Neural Tube Formation Pro-B Cell Differentiation Mitral Valve Morphogenesis Cardiac Ventricle Formation Cardiac Right Ventricle Morphogenesis Atrial Septum Primum Morphogenesis Noradrenergic Neuron Differentiation Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Glial Cell Proliferation Spinal Cord Development Spinal Cord Motor Neuron Differentiation Glial Cell Development Cell Differentiation T Cell Differentiation Endocrine Pancreas Development Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Positive Regulation Of Insulin Secretion Somatic Stem Cell Population Maintenance Ascending Aorta Morphogenesis Glucose Homeostasis DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Protein Stabilization Limb Bud Formation Ventricular Septum Morphogenesis Negative Regulation Of Cell Death Neuroepithelial Cell Differentiation Kidney Morphogenesis Hematopoietic Stem Cell Homeostasis Cellular Response To Glucose Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of N-terminal Peptidyl-lysine Acetylation	MAPK Cascade Osteoblast Differentiation Metanephros Development Response To Hypoxia Liver Development Negative Regulation Of Endothelial Cell Proliferation Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Cell Communication Ras Protein Signal Transduction Negative Regulation Of Neuroblast Proliferation Brain Development Peripheral Nervous System Development Heart Development Visual Learning Schwann Cell Development Phosphatidylinositol 3-kinase Signaling Spinal Cord Development Forebrain Astrocyte Development Cerebral Cortex Development Myelination In Peripheral Nervous System Actin Cytoskeleton Organization Extracellular Matrix Organization Collagen Fibril Organization Adrenal Gland Development Negative Regulation Of Cell Migration Wound Healing Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Pigmentation Positive Regulation Of Neuron Apoptotic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Regulation Of Bone Resorption Regulation Of Glial Cell Differentiation Positive Regulation Of Adenylate Cyclase Activity Regulation Of Angiogenesis Negative Regulation Of Fibroblast Proliferation Sympathetic Nervous System Development Camera-type Eye Morphogenesis Negative Regulation Of Oligodendrocyte Differentiation Smooth Muscle Tissue Development Artery Morphogenesis Forebrain Morphogenesis Cognition
Pathways		Deactivation of the beta-catenin transactivating complex	Regulation of RAS by GAPs RAS signaling downstream of NF1 loss-of-function variants
Drugs
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Bone mineral density ( 21533022) Cardiac hypertrophy ( 21348951) Endometrial cancer ( 30093612 27008869) Endometrial cancer (endometrioid histology) ( 30093612) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291)	Adventurousness ( 30643258) Apolipoprotein B levels ( 32203549) Bitter alcoholic beverage consumption ( 31046077) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Familial squamous cell lung carcinoma ( 29924316) Feeling nervous ( 29500382) General risk tolerance (MTAG) ( 30643258) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Monocyte percentage of white cells ( 32888494) Oily fish consumption ( 32066663) Platelet count ( 32888494) Plateletcrit ( 32888494) Pork consumption ( 32066663) Total cholesterol levels ( 29083408) Type 2 diabetes ( 30297969 32499647)
Interacting Genes		34 interacting genes: AKT1 APOC3 AURKA CAPN15 CDKN2A CTR9 DACH1 EDF1 FOXH1 FZR1 IGF1 ITIH1 KRAS MINPP1 MNT MYC NANOGNB NF1 NF2 NSD3 PLD3 PLXNB1 RGSL1 RHOU RP1L1 SCNN1G SDCBP SMARCA4 STK11 TERT TNNI3 TSC1 UBE2I WT1	16 interacting genes: AKT1 APP CLK1 DNAJC7 EPHA2 GRIN1 GRIN2D HRAS HTR6 LIMK2 MAP2K3 RAF1 SDC2 SOX4 TBPL1 VCP
Entrez ID		6659	4763
HPRD ID		01695	01203
Ensembl ID		ENSG00000124766	ENSG00000196712
Uniprot IDs		Q06945	P21359
PDB IDs			1NF1 2D4Q 2E2X 3P7Z 3PEG 3PG7 6OB2 6OB3 6V65 6V6F
Enriched GO Terms of Interacting Partners?
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