SOX4 and APOC3

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SOX4	APOC3
Description		SRY-box transcription factor 4	apolipoprotein C3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion	Extracellular Region Extracellular Space Early Endosome Very-low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Phospholipid Binding Cholesterol Binding Enzyme Regulator Activity Lipase Inhibitor Activity High-density Lipoprotein Particle Receptor Binding
	Biological Process	Skeletal System Development Neural Tube Formation Pro-B Cell Differentiation Mitral Valve Morphogenesis Cardiac Ventricle Formation Cardiac Right Ventricle Morphogenesis Atrial Septum Primum Morphogenesis Noradrenergic Neuron Differentiation Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Glial Cell Proliferation Spinal Cord Development Spinal Cord Motor Neuron Differentiation Glial Cell Development Cell Differentiation T Cell Differentiation Endocrine Pancreas Development Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Positive Regulation Of Insulin Secretion Somatic Stem Cell Population Maintenance Ascending Aorta Morphogenesis Glucose Homeostasis DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Protein Stabilization Limb Bud Formation Ventricular Septum Morphogenesis Negative Regulation Of Cell Death Neuroepithelial Cell Differentiation Kidney Morphogenesis Hematopoietic Stem Cell Homeostasis Cellular Response To Glucose Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of N-terminal Peptidyl-lysine Acetylation	Retinoid Metabolic Process Triglyceride Metabolic Process G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Triglyceride Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of High-density Lipoprotein Particle Clearance Negative Regulation Of Low-density Lipoprotein Particle Clearance Triglyceride Catabolic Process Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux Chylomicron Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Lipoprotein Metabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Lipid Catabolic Process Negative Regulation Of Lipoprotein Lipase Activity Negative Regulation Of Cholesterol Import Triglyceride Homeostasis
Pathways		Deactivation of the beta-catenin transactivating complex	Chylomicron assembly Chylomicron remodeling HDL remodeling Retinoid metabolism and transport Retinoid metabolism and transport
Drugs			Copper Volanesorsen
Diseases
GWAS		Bone mineral density ( 21533022) Cardiac hypertrophy ( 21348951) Endometrial cancer ( 30093612 27008869) Endometrial cancer (endometrioid histology) ( 30093612) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291)	Blood protein levels ( 30072576) Body mass index ( 31978080) Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990) Delirium ( 29631748) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 28270201 20864672 19060906 30275531 20686565 26582766) HDL cholesterol levels ( 28334899) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 28548082) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 18179892 20864672 19060911 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 30576415 24386095) Lipoprotein (a) - cholesterol levels ( 25575512) Metabolite levels ( 22916037) Platelet count ( 27863252) Plateletcrit ( 32888494 27863252) Postprandial triglyceride levels ( 32603185) Red cell distribution width ( 32888494) Refractive error ( 32231278) Total cholesterol levels ( 28334899) Triglyceride levels ( 28334899 26763881 28371326 28548082) Triglycerides ( 19074352 21909109 18193043 18193044 20864672 19060906 19060911 20139978 20686565 26582766)
Interacting Genes		34 interacting genes: AKT1 APOC3 AURKA CAPN15 CDKN2A CTR9 DACH1 EDF1 FOXH1 FZR1 IGF1 ITIH1 KRAS MINPP1 MNT MYC NANOGNB NF1 NF2 NSD3 PLD3 PLXNB1 RGSL1 RHOU RP1L1 SCNN1G SDCBP SMARCA4 STK11 TERT TNNI3 TSC1 UBE2I WT1	6 interacting genes: ARFGAP1 ERGIC3 FAM209A GPX8 SOX4 VKORC1
Entrez ID		6659	345
HPRD ID		01695	00132
Ensembl ID		ENSG00000124766	ENSG00000110245
Uniprot IDs		Q06945	A3KPE2 P02656
PDB IDs			2JQ3
Enriched GO Terms of Interacting Partners?
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