SOX4 and MINPP1

Data Source:
BioGRID (two hybrid)

		SOX4	MINPP1
Description		SRY-box transcription factor 4	multiple inositol-polyphosphate phosphatase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Extracellular Exosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific Double-stranded DNA Binding	Acid Phosphatase Activity Protein Binding Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Bisphosphoglycerate 3-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol Phosphate Phosphatase Activity Inositol Hexakisphosphate 2-phosphatase Activity Protein Histidine Phosphatase Activity
	Biological Process	Skeletal System Development Neural Tube Formation Pro-B Cell Differentiation Mitral Valve Morphogenesis Cardiac Ventricle Formation Cardiac Right Ventricle Morphogenesis Atrial Septum Primum Morphogenesis Noradrenergic Neuron Differentiation Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Glial Cell Proliferation Spinal Cord Development Spinal Cord Motor Neuron Differentiation Glial Cell Development Cell Differentiation T Cell Differentiation Endocrine Pancreas Development Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Positive Regulation Of Insulin Secretion Somatic Stem Cell Population Maintenance Ascending Aorta Morphogenesis Glucose Homeostasis DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Protein Stabilization Limb Bud Formation Ventricular Septum Morphogenesis Negative Regulation Of Cell Death Neuroepithelial Cell Differentiation Kidney Morphogenesis Hematopoietic Stem Cell Homeostasis Cellular Response To Glucose Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of N-terminal Peptidyl-lysine Acetylation	Ossification Protein Dephosphorylation Polyphosphate Metabolic Process Bone Mineralization Inositol Phosphate Metabolic Process
Pathways		Deactivation of the beta-catenin transactivating complex	Synthesis of IPs in the ER lumen
Drugs
Diseases
GWAS		Bone mineral density ( 21533022) Cardiac hypertrophy ( 21348951) Endometrial cancer ( 30093612 27008869) Endometrial cancer (endometrioid histology) ( 30093612) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291)	Blood protein levels ( 30072576) Forehead morphology ( 29921221) Longevity ( 20304771) Pursuit maintenance gain ( 29064472)
Interacting Genes		34 interacting genes: AKT1 APOC3 AURKA CAPN15 CDKN2A CTR9 DACH1 EDF1 FOXH1 FZR1 IGF1 ITIH1 KRAS MINPP1 MNT MYC NANOGNB NF1 NF2 NSD3 PLD3 PLXNB1 RGSL1 RHOU RP1L1 SCNN1G SDCBP SMARCA4 STK11 TERT TNNI3 TSC1 UBE2I WT1	4 interacting genes: ACTA1 SOX4 SRF UBQLN2
Entrez ID		6659	9562
HPRD ID		01695	05652
Ensembl ID		ENSG00000124766	ENSG00000107789
Uniprot IDs		Q06945	Q9UNW1
PDB IDs
Enriched GO Terms of Interacting Partners?
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