NF1 and GRIN1

Data Source:
HPRD (in vivo)

		NF1	GRIN1
Description		neurofibromin 1	glutamate ionotropic receptor NMDA type subunit 1
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Membrane Axon Dendrite	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density NMDA Selective Glutamate Receptor Complex Dendrite Neuron Projection Synaptic Cleft Terminal Bouton Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Synaptic Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylethanolamine Binding Phosphatidylcholine Binding	Amyloid-beta Binding NMDA Glutamate Receptor Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Ligand-gated Ion Channel Activity Glycine Binding Glutamate Binding Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Neurotransmitter Binding Protein-containing Complex Binding
	Biological Process	MAPK Cascade Osteoblast Differentiation Metanephros Development Response To Hypoxia Liver Development Negative Regulation Of Endothelial Cell Proliferation Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Cell Communication Ras Protein Signal Transduction Negative Regulation Of Neuroblast Proliferation Brain Development Peripheral Nervous System Development Heart Development Visual Learning Schwann Cell Development Phosphatidylinositol 3-kinase Signaling Spinal Cord Development Forebrain Astrocyte Development Cerebral Cortex Development Myelination In Peripheral Nervous System Actin Cytoskeleton Organization Extracellular Matrix Organization Collagen Fibril Organization Adrenal Gland Development Negative Regulation Of Cell Migration Wound Healing Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Pigmentation Positive Regulation Of Neuron Apoptotic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Regulation Of Bone Resorption Regulation Of Glial Cell Differentiation Positive Regulation Of Adenylate Cyclase Activity Regulation Of Angiogenesis Negative Regulation Of Fibroblast Proliferation Sympathetic Nervous System Development Camera-type Eye Morphogenesis Negative Regulation Of Oligodendrocyte Differentiation Smooth Muscle Tissue Development Artery Morphogenesis Forebrain Morphogenesis Cognition	MAPK Cascade Cation Transport Chemical Synaptic Transmission Brain Development Visual Learning Positive Regulation Of Calcium Ion Transport Into Cytosol Propylene Metabolic Process Calcium-mediated Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Membrane Potential Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity Protein Heterotetramerization Calcium Ion Homeostasis Excitatory Postsynaptic Potential Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta Response To Glycine Regulation Of NMDA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Cysteine-type Endopeptidase Activity
Pathways		Regulation of RAS by GAPs RAS signaling downstream of NF1 loss-of-function variants	EPHB-mediated forward signaling EPHB-mediated forward signaling Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs			Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Acamprosate Donepezil Guaifenesin Memantine Memantine Orphenadrine Phenobarbital Aripiprazole Prasterone 5,7-Dichlorokynurenic acid D-Serine Cycloleucine Milnacipran CNS-5161 Acetylcysteine Ketobemidone Gavestinel Agmatine Ifenprodil Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Adventurousness ( 30643258) Apolipoprotein B levels ( 32203549) Bitter alcoholic beverage consumption ( 31046077) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Familial squamous cell lung carcinoma ( 29924316) Feeling nervous ( 29500382) General risk tolerance (MTAG) ( 30643258) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Monocyte percentage of white cells ( 32888494) Oily fish consumption ( 32066663) Platelet count ( 32888494) Plateletcrit ( 32888494) Pork consumption ( 32066663) Total cholesterol levels ( 29083408) Type 2 diabetes ( 30297969 32499647)	Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Interacting Genes		16 interacting genes: AKT1 APP CLK1 DNAJC7 EPHA2 GRIN1 GRIN2D HRAS HTR6 LIMK2 MAP2K3 RAF1 SDC2 SOX4 TBPL1 VCP	57 interacting genes: ACTN2 AKAP9 APP BDKRB1 CALM1 CAMK2A CAMK2G CANX CDH2 CIT CLTC CTNNB1 DLG1 DLG2 DLG3 DLG4 DLGAP4 DNM1 DRD1 DUSP4 EPHB2 EPHB4 FUS FYN GRIN2A GRIN2B GRIN2D GRIN3A HNRNPU HRAS HSPA1A INA LNX1 LRP8 MAP2 MAP2K2 MYH9 NANOS1 NEFL NF1 PLAT PLCG1 PPP2R1A PPP2R2A PRKCA PRKCB PRKCE PRKCG PTAFR RAP2A RPS6KA3 SP3 SPTAN1 SYNGAP1 TJP1 TRAF3 TUBA4B
Entrez ID		4763	2902
HPRD ID		01203	15926
Ensembl ID		ENSG00000196712	ENSG00000176884
Uniprot IDs		P21359	Q05586 Q59GW0 Q5VSF9
PDB IDs		1NF1 2D4Q 2E2X 3P7Z 3PEG 3PG7 6OB2 6OB3 6V65 6V6F	2HQW 2NR1 3BYA 5H8F 5H8H 5H8N 5H8Q 5I2K 5I2N 5KCJ 5KDT 5TP9 5TPA 6IRA 6IRF 6IRG 6IRH
Enriched GO Terms of Interacting Partners?
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