SNCA and PLK2

Data Source:
BioGRID (enzymatic study)

		SNCA	PLK2
Description		synuclein alpha	polo like kinase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Cell Cortex Actin Cytoskeleton Membrane Inclusion Body Axon Growth Cone Platelet Alpha Granule Membrane Protein-containing Complex Neuronal Cell Body Axon Terminus Perinuclear Region Of Cytoplasm Supramolecular Fiber	Chromatin Spindle Pole Nucleus Cytoplasm Centrosome Centriole Cytosol Dendrite
	Molecular Function	SNARE Binding Magnesium Ion Binding Transcription Regulatory Region Sequence-specific DNA Binding Actin Binding Protein Kinase Inhibitor Activity Fatty Acid Binding Copper Ion Binding Calcium Ion Binding Protein Binding Phospholipid Binding Ferrous Iron Binding Zinc Ion Binding Oxidoreductase Activity Kinesin Binding Hsp70 Protein Binding Histone Binding Identical Protein Binding Alpha-tubulin Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Tau Protein Binding Phosphoprotein Binding Phospholipase D Inhibitor Activity Dynein Complex Binding Cuprous Ion Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding ATP-dependent Protein Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Microglial Cell Activation Positive Regulation Of Receptor Recycling Negative Regulation Of Protein Kinase Activity Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Chemical Synaptic Transmission Response To Iron(II) Ion Regulation Of Phospholipase Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Dopamine Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Priming Regulation Of Transmembrane Transporter Activity Negative Regulation Of Microtubule Polymerization Receptor Internalization Protein Destabilization Response To Magnesium Ion Negative Regulation Of Transporter Activity Response To Lipopolysaccharide Negative Regulation Of Monooxygenase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Response To Interferon-gamma Cellular Response To Oxidative Stress Negative Regulation Of Histone Acetylation SNARE Complex Assembly Positive Regulation Of SNARE Complex Assembly Dopamine Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Metabolic Process Positive Regulation Of Endocytosis Negative Regulation Of Exocytosis Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Inflammatory Response Synapse Organization Protein Tetramerization Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Regulation Of Norepinephrine Uptake Negative Regulation Of Norepinephrine Uptake Calcium Ion Homeostasis Positive Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Response To Interleukin-1 Cellular Response To Copper Ion Cellular Response To Epinephrine Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Supramolecular Fiber Organization Regulation Of Neuron Death Negative Regulation Of Neuron Death Positive Regulation Of Neuron Death Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Glutathione Peroxidase Activity Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Synaptic Vesicle Recycling Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Presynapse Assembly	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Mitotic Spindle Organization Mitotic Cell Cycle Checkpoint Ras Protein Signal Transduction Memory Positive Regulation Of Autophagy Negative Regulation Of Angiogenesis Peptidyl-serine Phosphorylation Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Rap Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Catabolic Process Regulation Of Centriole Replication Regulation Of Synaptic Plasticity Long-term Synaptic Potentiation Long-term Synaptic Depression Negative Regulation Of Dendritic Spine Development Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cellular Senescence
Pathways		Amyloid fiber formation	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CD163 mediating an anti-inflammatory response
Drugs		Resveratrol Copper	Fostamatinib
Diseases		Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)
GWAS		Blood protein levels ( 30072576 29875488) Dementia with Lewy bodies ( 29263008) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Feeling nervous ( 29500382) Neurociticism ( 29500382) Parkinson's disease ( 22451204 20711177 21084426 21292315 19915575 19915576 25064009 32201043 31660654 27182965 28892059 22438815 28011712 20070850 21044948 24511991 21738487 32310270) Parkinson's disease (age of onset) ( 31660654 30957308) Parkinson's disease in GBA mutation carriers ( 31755958) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Response to bupropion in depression ( 27622933)	Blond vs. brown/black hair color ( 30531825) Diastolic blood pressure ( 30224653) Esophageal adenocarcinoma x smoking interaction ( 29551738) Triglyceride levels ( 32203549) Type 2 diabetes (age of onset) ( 28060188) Working memory ( 31598132)
Interacting Genes		126 interacting genes: A1BG ACTA1 ADAP2 ADRB2 AKT1 AMBRA1 ANXA6 APLP1 APP ARHGAP15 ARPP19 ARSA BAD BAG5 BCL2L1 BDH2 CALM1 CAV1 CDC42EP2 CDC42EP3 CDC42SE1 CDK4 CHRM5 COL25A1 CRYAB CSNK1A1 CSNK1D CSNK2A1 CSNK2A2 CTNND1 CTSD CYCS DMTN DNAJC5 DOCK7 DYRK1A EEF1A1 EGFR EIF3G ELK1 ENC1 ENSA FBXL5 FGR FKBP4 FYN GABARAPL1 GAPDH GBA GRK1 GRK2 GRK5 GRK6 GSK3B H1-1 H1-2 HSD17B4 HSP90AA1 HSPB2 HSPB6 HSPB8 KIAA1191 KLC1 KLK6 LYN MAP1B MAPK1 MAPK8IP1 MAPT MEF2D MT-CO1 MT-CO3 NEDD4 NEDD4L PAK3 PARK7 PDE4DIP PDIA2 PELP1 PFDN2 PLCB2 PLD1 PLK1 PLK2 PLK3 PPP3CA PRDX1 PREP PRKCE PRKN PTK2B RABAC1 RNF10 SAP30BP SDF4 SEPTIN4 SIAH2 SLC6A3 SMURF2 SNCAIP SNCB SPTBN1 SQSTM1 SRC SRI STAMBP SYK SYN1 TGM1 TH TOR1A TPPP TUBA1A UBB UBC UBE2D2 UBE2W USP2 USP47 USP7 USP8 YOD1 YWHAB YWHAE YWHAH ZRANB1	10 interacting genes: APP CASK CDC20B CENPU CIB1 MPP3 NEDD4 SNCA TSC1 TSC2
Entrez ID		6622	10769
HPRD ID		01227	06118
Ensembl ID		ENSG00000145335	ENSG00000145632
Uniprot IDs		H6UYS5 P37840	A0A024QZV1 A0A087WUH9 Q9NYY3
PDB IDs		1XQ8 2JN5 2KKW 2M55 2N0A 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW 6A6B 6CT7 6CU7 6CU8 6FLT 6H6B 6I42 6L1T 6L1U 6L4S 6LRQ 6OSJ 6OSL 6OSM 6PEO 6PES 6RT0 6RTB 6SST 6SSX 6UFR 6XYO 6XYP 6XYQ	4I5M 4I5P 4I6B 4I6F 4I6H 4RS6 4XB0
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?