SNCA and PTK2B

Data Source:
HPRD (in vivo, in vitro)

		SNCA	PTK2B
Description		synuclein alpha	protein tyrosine kinase 2 beta
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Cell Cortex Actin Cytoskeleton Membrane Inclusion Body Axon Growth Cone Platelet Alpha Granule Membrane Protein-containing Complex Neuronal Cell Body Axon Terminus Perinuclear Region Of Cytoplasm Supramolecular Fiber	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Cortex Postsynaptic Density NMDA Selective Glutamate Receptor Complex Lamellipodium Dendrite Growth Cone Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuronal Cell Body Dendritic Spine Cell Body Membrane Raft Perinuclear Region Of Cytoplasm Apical Dendrite Glutamatergic Synapse
	Molecular Function	SNARE Binding Magnesium Ion Binding Transcription Regulatory Region Sequence-specific DNA Binding Actin Binding Protein Kinase Inhibitor Activity Fatty Acid Binding Copper Ion Binding Calcium Ion Binding Protein Binding Phospholipid Binding Ferrous Iron Binding Zinc Ion Binding Oxidoreductase Activity Kinesin Binding Hsp70 Protein Binding Histone Binding Identical Protein Binding Alpha-tubulin Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Tau Protein Binding Phosphoprotein Binding Phospholipase D Inhibitor Activity Dynein Complex Binding Cuprous Ion Binding	Calmodulin-dependent Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity NMDA Glutamate Receptor Activity Signaling Receptor Binding Protein Binding ATP Binding Protein C-terminus Binding Ubiquitin Protein Ligase Binding 3-phosphoinositide-dependent Protein Kinase Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Microglial Cell Activation Positive Regulation Of Receptor Recycling Negative Regulation Of Protein Kinase Activity Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Chemical Synaptic Transmission Response To Iron(II) Ion Regulation Of Phospholipase Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Dopamine Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Priming Regulation Of Transmembrane Transporter Activity Negative Regulation Of Microtubule Polymerization Receptor Internalization Protein Destabilization Response To Magnesium Ion Negative Regulation Of Transporter Activity Response To Lipopolysaccharide Negative Regulation Of Monooxygenase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Response To Interferon-gamma Cellular Response To Oxidative Stress Negative Regulation Of Histone Acetylation SNARE Complex Assembly Positive Regulation Of SNARE Complex Assembly Dopamine Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Metabolic Process Positive Regulation Of Endocytosis Negative Regulation Of Exocytosis Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Inflammatory Response Synapse Organization Protein Tetramerization Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Regulation Of Norepinephrine Uptake Negative Regulation Of Norepinephrine Uptake Calcium Ion Homeostasis Positive Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Response To Interleukin-1 Cellular Response To Copper Ion Cellular Response To Epinephrine Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Supramolecular Fiber Organization Regulation Of Neuron Death Negative Regulation Of Neuron Death Positive Regulation Of Neuron Death Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Glutathione Peroxidase Activity Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Synaptic Vesicle Recycling Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Presynapse Assembly	MAPK Cascade Angiogenesis Oocyte Maturation Response To Hypoxia Positive Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Adaptive Immune Response Marginal Zone B Cell Differentiation Protein Phosphorylation Apoptotic Process Cellular Defense Response Response To Osmotic Stress Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Response To Mechanical Stimulus Response To Hormone Response To Glucose Response To Lithium Ion Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Muscle Cell Apoptotic Process Regulation Of CGMP-mediated Signaling Regulation Of Macrophage Chemotaxis Positive Regulation Of Neuron Projection Development Glial Cell Proliferation Peptidyl-tyrosine Phosphorylation Cell Differentiation Regulation Of Cell Adhesion Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Actin Filament Polymerization Neuron Projection Development Regulation Of Inositol Trisphosphate Biosynthetic Process Tumor Necrosis Factor-mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Response To Immobilization Stress Peptidyl-tyrosine Autophosphorylation Interleukin-2-mediated Signaling Pathway Response To Cocaine Response To Drug Response To Hydrogen Peroxide Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Stress Fiber Assembly Negative Regulation Of Potassium Ion Transport Positive Regulation Of JUN Kinase Activity Negative Regulation Of Neuron Apoptotic Process Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Bone Resorption Response To Ethanol Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Angiogenesis Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Regulation Of Synaptic Plasticity Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Calcium-mediated Signaling Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To CAMP Response To Calcium Ion Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Long-term Synaptic Depression Protein-containing Complex Assembly Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Fluid Shear Stress Endothelin Receptor Signaling Pathway Activation Of GTPase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Establishment Of Cell Polarity Regulation Of Actin Cytoskeleton Reorganization Regulation Of NMDA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of B Cell Chemotaxis Positive Regulation Of DNA Biosynthetic Process
Pathways		Amyloid fiber formation	Signal regulatory protein family interactions VEGFA-VEGFR2 Pathway Interleukin-2 signaling
Drugs		Resveratrol Copper	Leflunomide Genistein 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide Baricitinib Fostamatinib
Diseases		Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)
GWAS		Blood protein levels ( 30072576 29875488) Dementia with Lewy bodies ( 29263008) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Feeling nervous ( 29500382) Neurociticism ( 29500382) Parkinson's disease ( 22451204 20711177 21084426 21292315 19915575 19915576 25064009 32201043 31660654 27182965 28892059 22438815 28011712 20070850 21044948 24511991 21738487 32310270) Parkinson's disease (age of onset) ( 31660654 30957308) Parkinson's disease in GBA mutation carriers ( 31755958) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Response to bupropion in depression ( 27622933)	Adult body size ( 32376654) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Autism spectrum disorder or schizophrenia ( 28540026) Bone mineral content ( 31790847) Bone mineral density ( 31790847) Crohn's disease ( 26192919) Dental caries ( 23259602) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Family history of Alzheimer's disease ( 30617256) Inflammatory bowel disease ( 26192919) Schizophrenia ( 29483656) Takayasu arteritis ( 25604533 30498034) White blood cell count ( 32888494)
Interacting Genes		126 interacting genes: A1BG ACTA1 ADAP2 ADRB2 AKT1 AMBRA1 ANXA6 APLP1 APP ARHGAP15 ARPP19 ARSA BAD BAG5 BCL2L1 BDH2 CALM1 CAV1 CDC42EP2 CDC42EP3 CDC42SE1 CDK4 CHRM5 COL25A1 CRYAB CSNK1A1 CSNK1D CSNK2A1 CSNK2A2 CTNND1 CTSD CYCS DMTN DNAJC5 DOCK7 DYRK1A EEF1A1 EGFR EIF3G ELK1 ENC1 ENSA FBXL5 FGR FKBP4 FYN GABARAPL1 GAPDH GBA GRK1 GRK2 GRK5 GRK6 GSK3B H1-1 H1-2 HSD17B4 HSP90AA1 HSPB2 HSPB6 HSPB8 KIAA1191 KLC1 KLK6 LYN MAP1B MAPK1 MAPK8IP1 MAPT MEF2D MT-CO1 MT-CO3 NEDD4 NEDD4L PAK3 PARK7 PDE4DIP PDIA2 PELP1 PFDN2 PLCB2 PLD1 PLK1 PLK2 PLK3 PPP3CA PRDX1 PREP PRKCE PRKN PTK2B RABAC1 RNF10 SAP30BP SDF4 SEPTIN4 SIAH2 SLC6A3 SMURF2 SNCAIP SNCB SPTBN1 SQSTM1 SRC SRI STAMBP SYK SYN1 TGM1 TH TOR1A TPPP TUBA1A UBB UBC UBE2D2 UBE2W USP2 USP47 USP7 USP8 YOD1 YWHAB YWHAE YWHAH ZRANB1	69 interacting genes: ARHGAP21 ARHGAP5 ASAP1 ASAP2 BCAR1 CBL CCR5 CRK DLG3 DLG4 DLGAP3 EFS EGFR ERBB2 ERBB3 EWSR1 FGFR2 FGFR3 FLT1 FYN GNA13 GRB2 GRIN2A GSN IL7R ITGB2 ITGB3 JAK1 JAK2 JAK3 KCNA2 LCK LPXN LYN MAP3K4 MAPT MATK MCAM MYH2 NEDD9 NPHP1 PDCD6IP PDPK1 PIK3R1 PITPNM1 PITPNM2 PITPNM3 PRKCD PTK2 PTPN11 PTPN12 PTPN6 PXN RASA1 RB1CC1 SH2D3C SHC1 SKAP2 SLC2A1 SNCA SORBS2 SRC STAP1 STAT3 SYK TGFB1I1 TLN1 VAV1 ZAP70
Entrez ID		6622	2185
HPRD ID		01227	03131
Ensembl ID		ENSG00000145335	ENSG00000120899
Uniprot IDs		H6UYS5 P37840	Q14289
PDB IDs		1XQ8 2JN5 2KKW 2M55 2N0A 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW 6A6B 6CT7 6CU7 6CU8 6FLT 6H6B 6I42 6L1T 6L1U 6L4S 6LRQ 6OSJ 6OSL 6OSM 6PEO 6PES 6RT0 6RTB 6SST 6SSX 6UFR 6XYO 6XYP 6XYQ	2FO6 2LK4 3CC6 3ET7 3FZO 3FZP 3FZR 3FZS 3FZT 3GM1 3GM2 3GM3 3H3C 3U3F 4EKU 4H1J 4H1M 4R32 4XEF 4XEK 4XEV 5TO8 5TOB 6LF3
Enriched GO Terms of Interacting Partners?
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