SMARCC2 and SRGAP3

Data Source:
HPRD (in vivo)

		SMARCC2	SRGAP3
Description		SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2	SLIT-ROBO Rho GTPase activating protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm SWI/SNF Complex Protein-containing Complex NpBAF Complex NBAF Complex	Cytoplasm Cytosol
	Molecular Function	Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding Histone Binding	GTPase Activator Activity Protein Binding
	Biological Process	Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated	Signal Transduction Negative Regulation Of Cell Migration Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Rho GTPase cycle Inactivation of CDC42 and RAC1
Drugs
Diseases
GWAS		Asthma ( 31619474) Refractive error ( 32231278)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Body fat percentage ( 31752434) Lead levels in blood ( 25820613) Rapid automised naming of letters ( 30741946)
Interacting Genes		26 interacting genes: ARRB2 ATXN1 ATXN1L BAZ1B CSNK2A1 EWSR1 FUS GATA1 IFTAP ITCH ITSN1 KLF1 KRT27 MCPH1 NOVA1 PEX14 PHYHIP POLR2C RAB1B RELB SMARCB1 SP1 SRGAP3 TAF15 TERF1 TERF2IP	11 interacting genes: DISC1 DTNBP1 ENKD1 FASLG KDM1A PRMT6 RAC1 SMARCC2 SUV39H1 TNIK WASF1
Entrez ID		6601	9901
HPRD ID		03437	12108
Ensembl ID		ENSG00000139613	ENSG00000196220
Uniprot IDs		A0A024RB22 F8VXC8 Q8TAQ2	O43295
PDB IDs		6KAG 6LTH 6LTJ
Enriched GO Terms of Interacting Partners?
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