RASAL3 and DEF6

Data Source:
BioGRID (two hybrid)

		RASAL3	DEF6
Description		RAS protein activator like 3	DEF6 guanine nucleotide exchange factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cell Cortex Membrane Extracellular Exosome Cytoplasmic Side Of Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Filopodium Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	MAPK Cascade Positive Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction Positive Regulation Of NK T Cell Proliferation
Pathways		Regulation of RAS by GAPs
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)	Apolipoprotein A1 levels ( 32203549) Height ( 18391951) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 28714469) White blood cell count ( 32888494)
Interacting Genes		23 interacting genes: AMOTL2 BEGAIN CCDC102B CCDC136 CDR2L DEF6 HNRNPK HOMER1 KHDRBS3 KRT27 MTUS2 NTAQ1 PICK1 PPP1R13B PRKAA2 RABGEF1 RASD1 SNRPA TP53BP2 WASF3 YWHAE YWHAZ ZRANB1	32 interacting genes: APP ARHGAP22 BEGAIN CCDC88B CDC42 CDC42EP1 EIF4ENIF1 GOLGA6A GOLGA6L9 HOMEZ INCA1 INTS2 KIAA1328 KRT31 L3MBTL3 LCK PBXIP1 PLSCR1 PSMA1 PTK2 RAC1 RAC2 RAPGEF4 RASAL3 REL RHOA SAP18 SLU7 TCF4 TEPSIN ZAP70 ZNF688
Entrez ID		64926	50619
HPRD ID		10977	10869
Ensembl ID		ENSG00000105122	ENSG00000023892
Uniprot IDs		Q86YV0	Q9H4E7
PDB IDs
Enriched GO Terms of Interacting Partners?
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