SIAH2 and SNCAIP

Data Source:
BioGRID (enzymatic study)

		SIAH2	SNCAIP
Description		siah E3 ubiquitin protein ligase 2	synuclein alpha interacting protein
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Early Endosome Cytosol Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle	Nucleoplasm Cytoplasm Cytosol Synaptic Vesicle Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Neuronal Cell Body
	Molecular Function	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cell Cycle Small GTPase Mediated Signal Transduction Multicellular Organism Development Protein Deubiquitination Regulation Of Protein Ubiquitination Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Rhythmic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Netrin-activated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Cell Death Dopamine Metabolic Process Cellular Protein Metabolic Process Regulation Of Neurotransmitter Secretion Regulation Of Inclusion Body Assembly
Pathways		Netrin-1 signaling Ub-specific processing proteases Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	Amyloid fiber formation
Drugs
Diseases
GWAS		BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 22951594 31757997)	Chronic kidney disease (end stage renal disease vs. normal eGFR) in type 1 diabetes ( 31537649) Delirium ( 29631748) Depressive symptoms x independent stressful life events interaction (2df test) ( 30718454) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Mood disorder and prion disease ( 25897833) Response to paclitaxel in ovarian cancer (Caspase 3/7 EC50) ( 27047539)
Interacting Genes		43 interacting genes: AFF1 AKR1C3 ATN1 CACYBP CCBE1 CHEK2 DCC DYRK2 EEF1D EGLN3 HIPK2 HIPK3 MYD88 NRF1 OPRM1 PEG10 PEG3 PIAS2 PIAS3 PML POU2AF1 PSMD4 RBBP8 SETD2 SNCA SNCAIP SPRY2 STAT3 SYP TINF2 TP53BP2 TPX2 TRAF2 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2L6 UBE2N UBE2V2 USP13 USP19 VAV1	19 interacting genes: AGXT C11orf58 GET4 GSK3B NUB1 NUDT21 PIN1 PINK1 PPHLN1 PRKN PTN RNF19A SEPTIN4 SH2D3C SIAH1 SIAH2 SNCA TLE5 UBB
Entrez ID		6478	9627
HPRD ID		03737	04804
Ensembl ID		ENSG00000181788	ENSG00000064692
Uniprot IDs		O43255	B7Z616 B7Z995 Q6L981 Q6L983 Q9Y6H5
PDB IDs		5H9M	2KES
Enriched GO Terms of Interacting Partners?
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