SNCAIP and SEPTIN4

Data Source:
HPRD (in vivo)

		SNCAIP	SEPTIN4
Description		synuclein alpha interacting protein	septin 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Synaptic Vesicle Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Neuronal Cell Body	Nucleus Nucleoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Septin Ring Synaptic Vesicle Microtubule Cytoskeleton Septin Complex Cell Division Site Sperm Annulus
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding	Magnesium Ion Binding GTPase Activity Structural Molecule Activity Protein Binding GTP Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Cell Death Dopamine Metabolic Process Cellular Protein Metabolic Process Regulation Of Neurotransmitter Secretion Regulation Of Inclusion Body Assembly	Apoptotic Process Spermatogenesis Regulation Of Exocytosis Cell Differentiation Positive Regulation Of Protein Ubiquitination Cellular Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cytoskeleton-dependent Cytokinesis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Amyloid fiber formation
Drugs
Diseases
GWAS		Chronic kidney disease (end stage renal disease vs. normal eGFR) in type 1 diabetes ( 31537649) Delirium ( 29631748) Depressive symptoms x independent stressful life events interaction (2df test) ( 30718454) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Mood disorder and prion disease ( 25897833) Response to paclitaxel in ovarian cancer (Caspase 3/7 EC50) ( 27047539)
Interacting Genes		19 interacting genes: AGXT C11orf58 GET4 GSK3B NUB1 NUDT21 PIN1 PINK1 PPHLN1 PRKN PTN RNF19A SEPTIN4 SH2D3C SIAH1 SIAH2 SNCA TLE5 UBB	9 interacting genes: AREL1 BCL2 PRKN SEPTIN5 SEPTIN8 SNCA SNCAIP SNCB XIAP
Entrez ID		9627	5414
HPRD ID		04804	04738
Ensembl ID		ENSG00000064692	ENSG00000108387
Uniprot IDs		B7Z616 B7Z995 Q6L981 Q6L983 Q9Y6H5	O43236
PDB IDs		2KES
Enriched GO Terms of Interacting Partners?
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