SNCAIP and NUB1

Data Source:
BioGRID (two hybrid)

		SNCAIP	NUB1
Description		synuclein alpha interacting protein	negative regulator of ubiquitin like proteins 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Synaptic Vesicle Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Neuronal Cell Body	Nucleoplasm Nucleolus Cytosol
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding	Protein Binding
	Biological Process	Cell Death Dopamine Metabolic Process Cellular Protein Metabolic Process Regulation Of Neurotransmitter Secretion Regulation Of Inclusion Body Assembly	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Interferon-gamma Response To Tumor Necrosis Factor Post-translational Protein Modification Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Amyloid fiber formation
Drugs
Diseases
GWAS		Chronic kidney disease (end stage renal disease vs. normal eGFR) in type 1 diabetes ( 31537649) Delirium ( 29631748) Depressive symptoms x independent stressful life events interaction (2df test) ( 30718454) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Mood disorder and prion disease ( 25897833) Response to paclitaxel in ovarian cancer (Caspase 3/7 EC50) ( 27047539)	Body fat mass ( 28552196) Carotid plaque burden ( 28282560) Eyebrow thickness ( 26926045)
Interacting Genes		19 interacting genes: AGXT C11orf58 GET4 GSK3B NUB1 NUDT21 PIN1 PINK1 PPHLN1 PRKN PTN RNF19A SEPTIN4 SH2D3C SIAH1 SIAH2 SNCA TLE5 UBB	12 interacting genes: AIPL1 COPB1 FANCA NEDD8 PSMD2 PSMD4 SF3B4 SNCAIP UBD UBE2K UFD1 VCP
Entrez ID		9627	51667
HPRD ID		04804	07450
Ensembl ID		ENSG00000064692	ENSG00000013374
Uniprot IDs		B7Z616 B7Z995 Q6L981 Q6L983 Q9Y6H5	A0A090N8Q5 H3BM14 H3BM74 Q9Y5A7
PDB IDs		2KES	1WJU
Enriched GO Terms of Interacting Partners?
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