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SIAH2 and AKR1C3
Data Source:
BioGRID
(affinity chromatography technology, pull down)
SIAH2
AKR1C3
Description
siah E3 ubiquitin protein ligase 2
aldo-keto reductase family 1 member C3
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Early Endosome
Cytosol
Neuron Projection
Neuronal Cell Body
Intracellular Membrane-bounded Organelle
Nucleus
Cytoplasm
Cytosol
Extracellular Exosome
Molecular Function
Transcription Corepressor Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Activity
Retinal Dehydrogenase Activity
Alditol:NADP+ 1-oxidoreductase Activity
Aldo-keto Reductase (NADP) Activity
Estradiol 17-beta-dehydrogenase Activity
Retinol Dehydrogenase Activity
Steroid Dehydrogenase Activity
Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor
Phenanthrene 9,10-monooxygenase Activity
Bile Acid Binding
Dihydrotestosterone 17-beta-dehydrogenase Activity
Prostaglandin H2 Endoperoxidase Reductase Activity
Prostaglandin D2 11-ketoreductase Activity
Geranylgeranyl Reductase Activity
Ketoreductase Activity
Prostaglandin-F Synthase Activity
15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity
Androsterone Dehydrogenase Activity
5alpha-androstane-3beta,17beta-diol Dehydrogenase Activity
Testosterone Dehydrogenase (NAD+) Activity
Androstan-3-alpha,17-beta-diol Dehydrogenase Activity
Testosterone 17-beta-dehydrogenase (NADP+) Activity
Ketosteroid Monooxygenase Activity
Delta4-3-oxosteroid 5beta-reductase Activity
NADP-retinol Dehydrogenase Activity
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Cell Cycle
Small GTPase Mediated Signal Transduction
Multicellular Organism Development
Protein Deubiquitination
Regulation Of Protein Ubiquitination
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Protein Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Rhythmic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Netrin-activated Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Retinoid Metabolic Process
Prostaglandin Metabolic Process
G Protein-coupled Receptor Signaling Pathway
Response To Nutrient
Steroid Metabolic Process
Positive Regulation Of Cell Population Proliferation
Male Gonad Development
Cellular Response To Starvation
Positive Regulation Of Cell Death
Farnesol Catabolic Process
Cyclooxygenase Pathway
Keratinocyte Differentiation
Cellular Response To Reactive Oxygen Species
Progesterone Metabolic Process
Retinol Metabolic Process
Retinal Metabolic Process
Macromolecule Metabolic Process
Daunorubicin Metabolic Process
Doxorubicin Metabolic Process
Regulation Of Retinoic Acid Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Testosterone Biosynthetic Process
Renal Absorption
Cellular Response To Cadmium Ion
Cellular Response To Calcium Ion
Cellular Response To Prostaglandin Stimulus
Cellular Response To Corticosteroid Stimulus
Cellular Response To Jasmonic Acid Stimulus
Cellular Response To Prostaglandin D Stimulus
Negative Regulation Of Retinoic Acid Biosynthetic Process
Regulation Of Testosterone Biosynthetic Process
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Netrin-1 signaling
Ub-specific processing proteases
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
RA biosynthesis pathway
Retinoid metabolism and transport
Drugs
NADH
Indomethacin
Androstenedione
Rutin
Prostaglandin D2
Flufenamic acid
Nicotinamide adenine dinucleotide phosphate
3-carboxamido-1,3,5(10)-estratrien-17(R)-spiro-2'(5',5'-dimethyl-6'oxo)tetrahydropyran
Diseases
GWAS
BRCA1/2-negative high-risk breast cancer (
30323354
)
Breast cancer (
22951594
31757997
)
Epithelial ovarian cancer (
31469419
)
Interacting Genes
43 interacting genes:
AFF1
AKR1C3
ATN1
CACYBP
CCBE1
CHEK2
DCC
DYRK2
EEF1D
EGLN3
HIPK2
HIPK3
MYD88
NRF1
OPRM1
PEG10
PEG3
PIAS2
PIAS3
PML
POU2AF1
PSMD4
RBBP8
SETD2
SNCA
SNCAIP
SPRY2
STAT3
SYP
TINF2
TP53BP2
TPX2
TRAF2
UBE2D1
UBE2D2
UBE2D3
UBE2I
UBE2L6
UBE2N
UBE2V2
USP13
USP19
VAV1
6 interacting genes:
ACIN1
LRIF1
MAGEA11
SIAH2
UBE2W
ZHX1
Entrez ID
6478
8644
HPRD ID
03737
04911
Ensembl ID
ENSG00000181788
ENSG00000196139
Uniprot IDs
O43255
A0A0A0MSS8
B4DKT3
P42330
PDB IDs
5H9M
1RY0
1RY8
1S1P
1S1R
1S2A
1S2C
1XF0
1ZQ5
2F38
2FGB
3R43
3R58
3R6I
3R7M
3R8G
3R8H
3R94
3UFY
3UG8
3UGR
3UWE
4DBS
4DBU
4DBW
4DZ5
4FA3
4FAL
4FAM
4H7C
4HMN
4WDT
4WDU
4WDW
4WDX
4WRH
4XVD
4XVE
4YVV
4YVX
4ZFC
5HNT
5HNU
6A7B
6F2U
6F78
6GXK
7C7F
7C7G
7C7H
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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