MEAF6 and L3MBTL2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MEAF6	L3MBTL2
Description		MYST/Esa1 associated factor 6	L3MBTL histone methyl-lysine binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleoplasm Nucleolus NuA4 Histone Acetyltransferase Complex MOZ/MORF Histone Acetyltransferase Complex NuA3a Histone Acetyltransferase Complex NuA3b Histone Acetyltransferase Complex	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Histone Acetyltransferase Activity (H3-K23 Specific)	Chromatin Binding Protein Binding Zinc Ion Binding Methylated Histone Binding Histone Binding
	Biological Process	Histone H2A Acetylation Histone H3-K23 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation Histone H3-K14 Acetylation Regulation Of Signal Transduction By P53 Class Mediator	Chromatin Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition
Pathways		HATs acetylate histones HATs acetylate histones Regulation of TP53 Activity through Acetylation	SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Eyebrow thickness ( 26926045)	Adventurousness ( 30643258) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 26192919) Depression ( 29700475) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 26192919) Lamb consumption ( 32066663) Major depressive disorder ( 27479909) Neuroticism ( 29255261 27918536) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		9 interacting genes: C2CD6 CCDC85B FXR2 JADE2 L3MBTL2 LDOC1 MRGBP PLEKHF2 TRIM54	49 interacting genes: AMOTL2 BEND7 BHLHB9 BIVM CARD9 CCDC106 CCDC33 CEP76 EFHC2 EIF4ENIF1 FAM217B GAS8 GKAP1 GOLGA2 H3C1 H4C1 HSF2BP LNX2 MEAF6 MEOX1 MPP3 NRF1 PAICS PHF10 PIAS1 PICK1 POU6F2 PRKAR1B RBAK REL SSUH2 STAC3 STAM2 TAX1BP1 TBC1D9B TEKT1 THAP1 THAP11 TLE5 TNNI1 TRIM42 TRIM50 TSPYL1 ZBTB26 ZBTB48 ZFP64 ZFY ZNF467 ZNF829
Entrez ID		64769	83746
HPRD ID		13347	13954
Ensembl ID		ENSG00000163875	ENSG00000100395
Uniprot IDs		Q9HAF1	A0A0S2Z5X6 Q969R5
PDB IDs			2W0T 3CEY 3F70
Enriched GO Terms of Interacting Partners?
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