AKTIP and TWNK

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		AKTIP	TWNK
Description		AKT interacting protein	twinkle mtDNA helicase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane HOPS Complex FHF Complex	Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity	Protease Binding DNA Helicase Activity Single-stranded DNA Binding ATP Binding Identical Protein Binding 5'-3' DNA Helicase Activity
	Biological Process	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Apoptotic Process Cellular Response To DNA Damage Stimulus Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Protein Phosphopantetheinylation Positive Regulation Of Protein Binding Early Endosome To Late Endosome Transport	Mitochondrial DNA Replication DNA Unwinding Involved In DNA Replication Mitochondrial Transcription Mitochondrion Organization Protein Hexamerization Cellular Response To Glucose Stimulus
Pathways			Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases			Mitochondrial DNA depletion syndrome (MDS)
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depressive symptoms (SSRI exposure interaction) ( 25649181) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 25673412) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		34 interacting genes: ACTN2 AKT1 ASS1 CEP126 CTBP2 DMXL2 DZIP3 EXOC7 FHIP1B GTF3C1 HOOK1 HOOK2 HOOK3 IMMT IPO7 LMNA MAP3K7 MARCHF5 MATR3 NEB PDE4DIP PDPK1 POLA2 RASGRF2 RPA1 TRIM23 TRIM32 TRIM41 TWNK UPF2 UTP14A VPS16 VPS18 VPS41	2 interacting genes: AKTIP SMAD9
Entrez ID		64400	56652
HPRD ID		07467	05830
Ensembl ID		ENSG00000166971	ENSG00000107815
Uniprot IDs		A0A024R6S6 A0A024R6T5 Q9H8T0	A0A2R8Y4V4 A0A2R8Y746 E5KSY5 Q96RR1 Q9H6V3
PDB IDs
Enriched GO Terms of Interacting Partners?
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