AKTIP and HOOK1

Data Source:
BioGRID (affinity chromatography technology, proximity labelling technology, two hybrid)
HPRD (in vivo)

		AKTIP	HOOK1
Description		AKT interacting protein	hook microtubule tethering protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane HOPS Complex FHF Complex	Cytoplasm Centrosome Cytosol Microtubule HOPS Complex FHF Complex
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity	Actin Binding Protein Binding Microtubule Binding Identical Protein Binding Dynein Light Intermediate Chain Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Apoptotic Process Cellular Response To DNA Damage Stimulus Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Protein Phosphopantetheinylation Positive Regulation Of Protein Binding Early Endosome To Late Endosome Transport	Golgi Organization Endosome Organization Lysosome Organization Multicellular Organism Development Endosome To Lysosome Transport Protein Transport Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Manchette Assembly
Pathways
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depressive symptoms (SSRI exposure interaction) ( 25649181) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 25673412) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Alcoholic chronic pancreatitis ( 28754779) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		34 interacting genes: ACTN2 AKT1 ASS1 CEP126 CTBP2 DMXL2 DZIP3 EXOC7 FHIP1B GTF3C1 HOOK1 HOOK2 HOOK3 IMMT IPO7 LMNA MAP3K7 MARCHF5 MATR3 NEB PDE4DIP PDPK1 POLA2 RASGRF2 RPA1 TRIM23 TRIM32 TRIM41 TWNK UPF2 UTP14A VPS16 VPS18 VPS41	30 interacting genes: AKTIP ANK3 ANKRD23 CDC5L CDK4 CWF19L2 FAM161A FHIP1B HOOK2 HOOK3 LMO2 MEOX2 PIAS2 SYCE1 TBC1D7 TFIP11 USP2 UTP14C VPS16 VPS18 VPS39 VPS41 ZBTB47 ZNF250 ZNF35 ZNF572 ZNF655 ZNF764 ZNF785 ZNF80
Entrez ID		64400	51361
HPRD ID		07467	07428
Ensembl ID		ENSG00000166971	ENSG00000134709
Uniprot IDs		A0A024R6S6 A0A024R6T5 Q9H8T0	Q9UJC3
PDB IDs
Enriched GO Terms of Interacting Partners?
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