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UBQLN4 and HSPA5
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
UBQLN4
HSPA5
Description
ubiquilin 4
heat shock protein family A (Hsp70) member 5
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Autophagosome
Endoplasmic Reticulum Membrane
Cytosol
Cytoplasmic Vesicle
Nuclear Proteasome Complex
Cytosolic Proteasome Complex
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Site Of DNA Damage
Nucleus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
Plasma Membrane
Focal Adhesion
COP9 Signalosome
Cell Surface
Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Midbody
Protein-containing Complex
Endoplasmic Reticulum Chaperone Complex
Melanosome
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Molecular Function
Protein Binding
Polyubiquitin Modification-dependent Protein Binding
K48-linked Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Calcium Ion Binding
Protein Binding
ATP Binding
ATPase Activity
Enzyme Binding
Protein Domain Specific Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ribosome Binding
Protein Folding Chaperone
Cadherin Binding
Unfolded Protein Binding
Chaperone Binding
Misfolded Protein Binding
Biological Process
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Autophagy
Cellular Response To DNA Damage Stimulus
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Autophagosome Maturation
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Luteolysis
ER Overload Response
Positive Regulation Of Neuron Projection Development
Cerebellum Structural Organization
Cerebellar Purkinje Cell Layer Development
Substantia Nigra Development
Neuron Differentiation
Positive Regulation Of Cell Migration
Ubiquitin-dependent ERAD Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Posttranslational Protein Targeting To Membrane, Translocation
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Protein Ubiquitination
Cellular Response To Unfolded Protein
Protein Folding In Endoplasmic Reticulum
Maintenance Of Protein Localization In Endoplasmic Reticulum
Cellular Response To Drug
IRE1-mediated Unfolded Protein Response
PERK-mediated Unfolded Protein Response
ATF6-mediated Unfolded Protein Response
Protein Refolding
Cellular Response To Glucose Starvation
Response To Cocaine
Negative Regulation Of Apoptotic Process
Chaperone Cofactor-dependent Protein Refolding
Neuron Apoptotic Process
Regulation Of Protein Folding In Endoplasmic Reticulum
Cellular Response To Antibiotic
Cellular Response To Calcium Ion
Cellular Response To Manganese Ion
Cellular Response To CAMP
Cellular Response To Interleukin-4
Cellular Response To Gamma Radiation
Stress Response To Metal Ion
Toxin Transport
Regulation Of ATF6-mediated Unfolded Protein Response
Regulation Of IRE1-mediated Unfolded Protein Response
Negative Regulation Of IRE1-mediated Unfolded Protein Response
Regulation Of PERK-mediated Unfolded Protein Response
Response To Methamphetamine Hydrochloride
Cellular Response To Nerve Growth Factor Stimulus
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways
Platelet degranulation
Regulation of HSF1-mediated heat shock response
ATF6 (ATF6-alpha) activates chaperones
PERK regulates gene expression
IRE1alpha activates chaperones
ATF6 (ATF6-alpha) activates chaperone genes
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Antihemophilic factor, human recombinant
Acetylsalicylic acid
Copper
Lonoctocog alfa
Moroctocog alfa
Diseases
GWAS
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Body mass index (
29273807
)
Crohn's disease (
28067908
)
General risk tolerance (MTAG) (
30643258
)
Inflammatory bowel disease (
28067908
23128233
)
Refractive error (
32231278
)
Interacting Genes
161 interacting genes:
ADAM33
ADPGK
AGR2
ANKRD13D
AREG
ARL4C
ATP5IF1
ATP5MK
ATXN1
BAG6
BPIFA1
C11orf49
C1orf94
C1QTNF1
CACNA1G
CCDC107
CCDC134
CCDC136
CCDC14
CCDC33
CCL21
CD99
CDSN
CEND1
COL8A1
COPB1
CPSF6
CRIPT
CSTF2
CSTF2T
CTSB
CYB5R1
DAZAP2
DKK3
DMPK
DNAJB11
DTX2
EAPP
EDN1
EEF1A1
EFEMP2
ELF5
EPDR1
ERP27
ERP29
FA2H
FGFBP1
FKBP2
FKBP7
FZD7
GABRD
GDI1
GJA1
GJA5
GJC1
GKAP1
GPX7
HAVCR1
HGS
HK2
HSPA13
HSPA5
IGFBP6
IGHM
IGLC1
IMMT
IMPDH2
ITPRIPL1
KLHL26
KLHL42
LAT2
MDK
MDM2
MIEF2
MIF4GD
MLLT6
MOAP1
MTNR1B
MYDGF
NAE1
NME3
NOMO1
NOMO3
NOTCH2NLA
NPHP1
NPPA
NXF1
OAT
ORC5
PBXIP1
PCDH17
PCDH8
PDIA5
PDLIM7
PELI2
PICK1
PIN1
PIP4K2B
PLAAT3
PMEPA1
PNMA1
PPIB
PPIC
PRL
PRPF40A
PTN
PTPRN
PTPRN2
QSOX1
RAD23A
RAI2
RBM10
RIC8A
RNF11
RNPS1
ROBO2
RPN1
RSRC2
RUNX1T1
RXRA
SCAF1
SCG2
SCG5
SCMH1
SEMG1
SERPINE1
SERPINH1
SERPINI2
SMAD3
SMAD9
SMARCB1
SPAG8
SPINT1
SPP1
SRGN
SRSF2
STAM2
STMN1
SUPT20H
TFF1
TGFB1I1
TNFRSF14
TNRC6B
TRAF2
TRIB2
TRIM32
UBC
UBQLN1
UBQLN2
UBR7
UNC119
UROS
VIP
WAC
YWHAQ
ZBTB22
ZDHHC3
ZFPM2
ZG16
ZG16B
ZNF205
70 interacting genes:
A2M
APC
APOB
BAG3
BCAR1
CASP7
CPT1A
DDX24
DNAJC1
DNAJC10
DNAJC3
DPH1
DPYSL5
EIF2AK3
ERBB2
ERCC6
ERN1
ERP29
F8
FCHSD2
GRB2
GRIA1
HLA-C
HMGB1
HSPB1
HSPBP1
HTR3A
IGHM
KRT14
KRT18
KRT8
LCT
LDLR
LINC01554
MATK
METTL21A
MTNR1A
MTNR1B
NDRG1
OTUD3
PARK7
PAWR
PCSK7
PRNP
PSME3
PTPN11
PTPRF
RPN1
SEC61A1
SEC63
SERPINB5
SH3BP4
SIL1
SIRPA
SQSTM1
SREBF2
STMN1
SUMO2
SUMO4
TCERG1
TG
TMEM132A
TMEM62
TRA
TSHR
UBE3A
UBQLN4
VHL
VWF
YWHAB
Entrez ID
56893
3309
HPRD ID
05670
00682
Ensembl ID
ENSG00000160803
ENSG00000044574
Uniprot IDs
B4DZF6
Q59F94
Q9NRR5
P11021
V9HWB4
PDB IDs
3IUC
3LDL
3LDN
3LDO
3LDP
5E84
5E85
5E86
5EVZ
5EX5
5EXW
5EY4
5F0X
5F1X
5F2R
6ASY
6CZ1
6DFM
6DFO
6DO2
6DWS
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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