SET and CDCA8

Data Source:
BioGRID (two hybrid)

		SET	CDCA8
Description		SET nuclear proto-oncogene	cell division cycle associated 8
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol Protein-containing Complex Perinuclear Region Of Cytoplasm	Chromosome, Centromeric Region Nucleoplasm Nucleolus Cytosol Chromocenter Midbody Chromosome Passenger Complex Protein-containing Complex Intercellular Bridge Spindle Midzone
	Molecular Function	DNA Binding Chromatin Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Regulator Activity Histone Binding	Protein Binding
	Biological Process	DNA Replication Nucleosome Assembly Nucleosome Disassembly Viral Process Negative Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Histone Acetylation Regulation Of MRNA Stability Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated	Mitotic Sister Chromatid Segregation Mitotic Metaphase Plate Congression Chromosome Organization Cell Division
Pathways		Condensation of Prophase Chromosomes HuR (ELAVL1) binds and stabilizes mRNA	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Axial length ( 24144296) Body mass index ( 26426971) Eating disorders (purging via substances) ( 23568457)	Axial length ( 24144296) Eyebrow thickness ( 26926045)
Interacting Genes		68 interacting genes: ANP32A APEX1 APP CALM1 CDCA8 CDK5 CDK5R1 CDKN1A CHAF1A CHRM2 CHRM3 ELAVL1 ELF4 ENO1 EP300 ESR1 FAM111B FBXO7 FOS FOXO1 GZMA GZMK H1-1 H2BC1 H3-3A H3-4 H4-16 H4C14 HMGB2 IRF1 JUNB KLF5 KMT2A LGMN MDM2 MEOX2 MTERF1 NME1 NUCB1 NUPR1 PAX6 PIK3CG PPP2CA PPP2R1B PRKAR1A PTEN PTMA RAC1 REPIN1 SDCBP SETBP1 SGO1 SGO2 TAF1A TERF1 TERF2 TERF2IP TEX35 THAP7 TLE5 TREX1 TRIM55 TRIM63 UCHL5 XRCC6 ZNF17 ZNF438 ZNF85	26 interacting genes: AURKB BIRC5 EMILIN1 FBXO17 GYS1 H3C14 HLA-DRB3 HMBOX1 INCENP MAPKAPK5 NEK3 NKAPD1 NTAQ1 PIAS2 PIH1D2 RANBP2 RPRD1B SENP3 SET SGO1 SGO2 SNAPC5 SPANXN2 TTK UBE2I ZNF277
Entrez ID		6418	55143
HPRD ID		09023	13017
Ensembl ID		ENSG00000119335	ENSG00000134690
Uniprot IDs		A0A024R895 A0A0C4DFV9 Q01105 Q5VXV3	Q53HL2
PDB IDs		2E50	2KDD 2QFA 2RAW 2RAX 6YIE 6YIF 6YIH
Enriched GO Terms of Interacting Partners?
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