SET and LGMN

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		SET	LGMN
Description		SET nuclear proto-oncogene	legumain
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol Protein-containing Complex Perinuclear Region Of Cytoplasm	Extracellular Region Cytoplasm Lysosome Late Endosome Endolysosome Lumen Lysosomal Lumen Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	DNA Binding Chromatin Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Regulator Activity Histone Binding	Cysteine-type Endopeptidase Activity Peptidase Activity Tau Protein Binding
	Biological Process	DNA Replication Nucleosome Assembly Nucleosome Disassembly Viral Process Negative Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Histone Acetylation Regulation Of MRNA Stability Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated	Toll-like Receptor Signaling Pathway Renal System Process Proteolysis Vacuolar Protein Processing Memory Positive Regulation Of Cell Population Proliferation Associative Learning Response To Acidic PH Negative Regulation Of Gene Expression Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Catabolic Process Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Multicellular Organism Growth Vitamin D Metabolic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Mitotic Cell Cycle Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Calcium Ion Positive Regulation Of Monocyte Chemotaxis Dendritic Spine Organization Activation Of Cysteine-type Endopeptidase Activity Self Proteolysis Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of ERBB Signaling Pathway Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Condensation of Prophase Chromosomes HuR (ELAVL1) binds and stabilizes mRNA	Trafficking and processing of endosomal TLR Vitamin D (calciferol) metabolism MHC class II antigen presentation
Drugs
Diseases
GWAS		Axial length ( 24144296) Body mass index ( 26426971) Eating disorders (purging via substances) ( 23568457)	Blood protein levels ( 30072576) Change in serum metabolite levels (CMS) ( 31636271) Systemic juvenile idiopathic arthritis ( 27927641)
Interacting Genes		68 interacting genes: ANP32A APEX1 APP CALM1 CDCA8 CDK5 CDK5R1 CDKN1A CHAF1A CHRM2 CHRM3 ELAVL1 ELF4 ENO1 EP300 ESR1 FAM111B FBXO7 FOS FOXO1 GZMA GZMK H1-1 H2BC1 H3-3A H3-4 H4-16 H4C14 HMGB2 IRF1 JUNB KLF5 KMT2A LGMN MDM2 MEOX2 MTERF1 NME1 NUCB1 NUPR1 PAX6 PIK3CG PPP2CA PPP2R1B PRKAR1A PTEN PTMA RAC1 REPIN1 SDCBP SETBP1 SGO1 SGO2 TAF1A TERF1 TERF2 TERF2IP TEX35 THAP7 TLE5 TREX1 TRIM55 TRIM63 UCHL5 XRCC6 ZNF17 ZNF438 ZNF85	5 interacting genes: LAMC3 MAPT SET SRPK2 USP17L2
Entrez ID		6418	5641
HPRD ID		09023	04017
Ensembl ID		ENSG00000119335	ENSG00000100600
Uniprot IDs		A0A024R895 A0A0C4DFV9 Q01105 Q5VXV3	Q53XC6 Q96CY7 Q99538
PDB IDs		2E50	4AW9 4AWA 4AWB 4FGU 4N6N 4N6O 5LU8 5LU9 5LUA 5LUB
Enriched GO Terms of Interacting Partners?
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