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MOAP1 and FZR1
Data Source:
BioGRID
(pull down, enzymatic study)
MOAP1
FZR1
Description
modulator of apoptosis 1
fizzy and cell division cycle 20 related 1
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Nuclear Membrane
Molecular Function
Protein Binding
Ubiquitin Protein Ligase Binding
Protein Binding
Anaphase-promoting Complex Binding
Ubiquitin Ligase Activator Activity
Biological Process
Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Positive Regulation Of Cell Population Proliferation
Anaphase-promoting Complex-dependent Catabolic Process
Regulation Of Meiotic Nuclear Division
Positive Regulation Of Protein Catabolic Process
Cell Division
Lens Fiber Cell Differentiation
Protein K11-linked Ubiquitination
Signal Transduction Involved In G2 DNA Damage Checkpoint
Negative Regulation Of Cell Aging
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Pathways
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of Emi1
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Body mass index (
26426971
)
Endometriosis (
23472165
)
Migraine (
27182965
)
Red cell distribution width (
32888494
)
Interacting Genes
23 interacting genes:
BAX
BCL2
BCL2L1
CACNA1A
CAMK2D
CCDC85B
DPPA2
FZR1
LATS1
MAGEH1
MBIP
MEOX2
PNMA5
PPP2R3C
RASSF1
RUSC1
THOC1
TNFRSF10A
TNFRSF1A
UBQLN2
UBQLN4
UBR5
ZMYND12
96 interacting genes:
AKT1
AKT1S1
ANAPC1
ANAPC10
ANAPC11
ANAPC2
ANAPC5
ANAPC7
ARNT
AURKA
BECN1
BEX1
BLID
BTRC
BUB1B
C7orf25
CCL5
CCNB1
CCND2
CCNE1
CCNF
CDC14A
CDC20
CDC25A
CDC27
CDC6
CDK2
CDK4
CDK5
CDK6
CDKN2A
CDKN2B
CDR2
CDT1
CLSPN
CYP17A1
DCPS
DKK3
DNAJA1
DNM1L
E2F3
EPHA2
EPSTI1
ERBB2
FBXO5
FGFR4
GLIS2
GMNN
HECW2
HIF1A
KAT2A
KIF18B
LATS2
MAD2L2
MAK
MAP2K3
MAP2K5
MAP3K5
MAPK8
MET
MOAP1
MTA3
MYC
NAT2
NEDD9
NEK2
NF2
OTUD7B
PAX3
PCLAF
PDGFRA
PLK1
PSMC3IP
PTP4A3
PTTG1
RASSF1
RBBP8
SASS6
SENP2
SIRT2
SKIL
SKP2
SMURF1
SOX2
SOX4
SRC
STK11
TEAD2
TERT
THRSP
TP53
UBE2C
UBE2D1
UBE2D3
UBE2K
UBE2S
Entrez ID
64112
51343
HPRD ID
17580
04687
Ensembl ID
ENSG00000165943
ENSG00000105325
Uniprot IDs
Q96BY2
Q9UM11
PDB IDs
4UI9
5L9T
5L9U
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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