FZR1 and TEAD2

Data Source:
BioGRID (fluorescent resonance energy transfer)

		FZR1	TEAD2
Description		fizzy and cell division cycle 20 related 1	TEA domain transcription factor 2
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GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol Nuclear Membrane	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Intracellular Membrane-bounded Organelle TEAD-YAP Complex
	Molecular Function	Protein Binding Anaphase-promoting Complex Binding Ubiquitin Ligase Activator Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Factor Activity Protein Binding Disordered Domain Specific Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Repair Ubiquitin-dependent Protein Catabolic Process Cell Cycle Positive Regulation Of Cell Population Proliferation Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Meiotic Nuclear Division Positive Regulation Of Protein Catabolic Process Cell Division Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Signal Transduction Involved In G2 DNA Damage Checkpoint Negative Regulation Of Cell Aging Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process	Vasculogenesis Neural Tube Closure Embryonic Heart Tube Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Notochord Development Hippo Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Development Lateral Mesoderm Development Embryonic Organ Development Negative Regulation Of Cell Death Protein-containing Complex Assembly Cellular Response To Retinoic Acid Regulation Of Stem Cell Differentiation
Pathways		Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription
Drugs
Diseases
GWAS		Red cell distribution width ( 32888494)
Interacting Genes		96 interacting genes: AKT1 AKT1S1 ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC5 ANAPC7 ARNT AURKA BECN1 BEX1 BLID BTRC BUB1B C7orf25 CCL5 CCNB1 CCND2 CCNE1 CCNF CDC14A CDC20 CDC25A CDC27 CDC6 CDK2 CDK4 CDK5 CDK6 CDKN2A CDKN2B CDR2 CDT1 CLSPN CYP17A1 DCPS DKK3 DNAJA1 DNM1L E2F3 EPHA2 EPSTI1 ERBB2 FBXO5 FGFR4 GLIS2 GMNN HECW2 HIF1A KAT2A KIF18B LATS2 MAD2L2 MAK MAP2K3 MAP2K5 MAP3K5 MAPK8 MET MOAP1 MTA3 MYC NAT2 NEDD9 NEK2 NF2 OTUD7B PAX3 PCLAF PDGFRA PLK1 PSMC3IP PTP4A3 PTTG1 RASSF1 RBBP8 SASS6 SENP2 SIRT2 SKIL SKP2 SMURF1 SOX2 SOX4 SRC STK11 TEAD2 TERT THRSP TP53 UBE2C UBE2D1 UBE2D3 UBE2K UBE2S	45 interacting genes: AKT1 ARNT AURKA BCL2L15 BECN1 C14orf39 CCND2 CDK4 CDK6 CDKN2A CDKN2B DACH1 EPHA2 FGFR4 FZR1 GLIS1 GLIS2 GNG13 HGF HIF1A INPP5A LATS2 MAP2K3 MAP2K5 MAP3K5 MYC NCOA1 NEDD4 NFIC NSD3 RAF1 RASSF1 RUNX1 SAA2 SOX3 STK11 TERT TP53 TRIM3 USF2 VGLL1 VGLL3 VGLL4 WWTR1 YAP1
Entrez ID		51343	8463
HPRD ID		04687	03432
Ensembl ID		ENSG00000105325	ENSG00000074219
Uniprot IDs		Q9UM11	A0A024QZE2 Q15562
PDB IDs		4UI9 5L9T 5L9U	3L15 5DQ8 5DQE 5EMV 5HGU 6CDY 6E5G 6S60 6S64 6S66 6S69 6S6J 6UYB 6UYC 6VAH
Enriched GO Terms of Interacting Partners?
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