FZR1 and LATS2

Data Source:
BioGRID (fluorescent resonance energy transfer)

		FZR1	LATS2
Description		fizzy and cell division cycle 20 related 1	large tumor suppressor kinase 2
Image
GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol Nuclear Membrane	Spindle Pole Nucleus Cytosol Centriolar Satellite
	Molecular Function	Protein Binding Anaphase-promoting Complex Binding Ubiquitin Ligase Activator Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	DNA Repair Ubiquitin-dependent Protein Catabolic Process Cell Cycle Positive Regulation Of Cell Population Proliferation Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Meiotic Nuclear Division Positive Regulation Of Protein Catabolic Process Cell Division Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Signal Transduction Involved In G2 DNA Damage Checkpoint Negative Regulation Of Cell Aging Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-serine Phosphorylation Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus
Pathways		Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Signaling by Hippo
Drugs
Diseases
GWAS		Red cell distribution width ( 32888494)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Refractive error ( 32231278)
Interacting Genes		96 interacting genes: AKT1 AKT1S1 ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC5 ANAPC7 ARNT AURKA BECN1 BEX1 BLID BTRC BUB1B C7orf25 CCL5 CCNB1 CCND2 CCNE1 CCNF CDC14A CDC20 CDC25A CDC27 CDC6 CDK2 CDK4 CDK5 CDK6 CDKN2A CDKN2B CDR2 CDT1 CLSPN CYP17A1 DCPS DKK3 DNAJA1 DNM1L E2F3 EPHA2 EPSTI1 ERBB2 FBXO5 FGFR4 GLIS2 GMNN HECW2 HIF1A KAT2A KIF18B LATS2 MAD2L2 MAK MAP2K3 MAP2K5 MAP3K5 MAPK8 MET MOAP1 MTA3 MYC NAT2 NEDD9 NEK2 NF2 OTUD7B PAX3 PCLAF PDGFRA PLK1 PSMC3IP PTP4A3 PTTG1 RASSF1 RBBP8 SASS6 SENP2 SIRT2 SKIL SKP2 SMURF1 SOX2 SOX4 SRC STK11 TEAD2 TERT THRSP TP53 UBE2C UBE2D1 UBE2D3 UBE2K UBE2S	67 interacting genes: ABL1 AJUBA AKT1 ARAF ARNT AURKA AURKB BECN1 BRAF CBLC CCND2 CCNE1 CD44 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C CHEK1 CHEK2 CTNNB1 DYRK1A EPHA2 ERBB2 EZH2 FGFR4 FHL3 FZR1 GLIS1 GLIS2 GRAP2 GRM1 HGF HIF1A KAT2A KDELR2 KIF23 MAP2K3 MAP2K5 MAPK14 MDM4 MET MOB3A MOB3B MOB3C MOB4 MYC NF2 NFIC PDGFRA RAF1 RASSF1 RELA SMAD2 SNAI1 STK11 STK3 SUZ12 TAZ TEAD2 TP53 TSC1 WWTR1 YWHAG YWHAZ
Entrez ID		51343	26524
HPRD ID		04687	07277
Ensembl ID		ENSG00000105325	ENSG00000150457
Uniprot IDs		Q9UM11	A0A024RDM3 Q9NRM7
PDB IDs		4UI9 5L9T 5L9U	4ZRI
Enriched GO Terms of Interacting Partners?
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