TSPYL2 and NOP53

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		TSPYL2	NOP53
Description		TSPY like 2	NOP53 ribosome biogenesis factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm	Fibrillar Center Nucleoplasm Nucleolus Cytosol RDNA Heterochromatin Intracellular Membrane-bounded Organelle
	Molecular Function	RDNA Binding Chromatin Binding Protein Binding Histone Binding	P53 Binding RNA Binding Protein Binding 5S RRNA Binding Identical Protein Binding
	Biological Process	Nucleosome Assembly Cell Cycle Negative Regulation Of DNA Replication Regulation Of Signal Transduction Negative Regulation Of Cell Growth IRE1-mediated Unfolded Protein Response Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity	Ribosomal Large Subunit Assembly Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Phosphorylation DNA Repair RRNA Processing Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of RIG-I Signaling Pathway Regulation Of Apoptotic Process Protein Stabilization Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling Cellular Response To Hypoxia Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Protein Localization To Nucleolus Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration Protein Localization To Nucleoplasm
Pathways		XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS
Interacting Genes		46 interacting genes: ABT1 AEBP2 APTX CASK CCNB1 CDK1 CDK2 CDK4 CEP19 COIL CREBBP CSNK2A1 EEF1A1 GFI1B H2BC15 HMGXB4 INO80B KMT5B LMO2 LNX1 MCRS1 NOL12 NOP53 PHF19 RBM15 RNF151 RPS25 SIRT6 SNIP1 TBC1D26 TMA16 TNNT1 TSPYL1 XAGE1A XAGE1B ZBTB24 ZBTB48 ZFP1 ZFP91 ZNF280C ZNF286A ZNF329 ZNF524 ZNF687 ZNF775 ZNF835	12 interacting genes: CCDC136 CDKN2A CEP70 HAP1 MDM2 PPP1CA PSMA1 SPTBN1 SRPK2 TP53 TSPYL2 UPF2
Entrez ID		64061	29997
HPRD ID		06713	16142
Ensembl ID		ENSG00000184205	ENSG00000105373
Uniprot IDs		Q9H2G4	Q9NZM5
PDB IDs
Enriched GO Terms of Interacting Partners?
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