TSPYL2 and KMT5B

Data Source:
BioGRID (two hybrid)

		TSPYL2	KMT5B
Description		TSPY like 2	lysine methyltransferase 5B
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm	Condensed Chromosome, Centromeric Region Nucleus Nucleoplasm
	Molecular Function	RDNA Binding Chromatin Binding Protein Binding Histone Binding	Chromatin Binding Protein Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H4-K20 Specific) Metal Ion Binding S-adenosyl-L-methionine Binding
	Biological Process	Nucleosome Assembly Cell Cycle Negative Regulation Of DNA Replication Regulation Of Signal Transduction Negative Regulation Of Cell Growth IRE1-mediated Unfolded Protein Response Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity	DNA Repair Muscle Organ Development Histone H4-K20 Trimethylation Positive Regulation Of Isotype Switching Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		XBP1(S) activates chaperone genes	PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Urate levels ( 31578528)
Interacting Genes		46 interacting genes: ABT1 AEBP2 APTX CASK CCNB1 CDK1 CDK2 CDK4 CEP19 COIL CREBBP CSNK2A1 EEF1A1 GFI1B H2BC15 HMGXB4 INO80B KMT5B LMO2 LNX1 MCRS1 NOL12 NOP53 PHF19 RBM15 RNF151 RPS25 SIRT6 SNIP1 TBC1D26 TMA16 TNNT1 TSPYL1 XAGE1A XAGE1B ZBTB24 ZBTB48 ZFP1 ZFP91 ZNF280C ZNF286A ZNF329 ZNF524 ZNF687 ZNF775 ZNF835	4 interacting genes: ESR1 H4C1 SMARCD1 TSPYL2
Entrez ID		64061	51111
HPRD ID		06713	11616
Ensembl ID		ENSG00000184205	ENSG00000110066
Uniprot IDs		Q9H2G4	B7WNX0 B7Z5N2 Q4FZB7
PDB IDs			3S8P 5CPR 5WBV
Enriched GO Terms of Interacting Partners?
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