NOP53 and UPF2

Data Source:
BioGRID (two hybrid)

		NOP53	UPF2
Description		NOP53 ribosome biogenesis factor	UPF2 regulator of nonsense mediated mRNA decay
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus Cytosol RDNA Heterochromatin Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Cytosol Polysome Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm
	Molecular Function	P53 Binding RNA Binding Protein Binding 5S RRNA Binding Identical Protein Binding	RNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Ribosomal Large Subunit Assembly Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Phosphorylation DNA Repair RRNA Processing Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of RIG-I Signaling Pathway Regulation Of Apoptotic Process Protein Stabilization Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling Cellular Response To Hypoxia Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Protein Localization To Nucleolus Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration Protein Localization To Nucleoplasm	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration
Pathways			Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Diverticular disease ( 30177863)
Interacting Genes		12 interacting genes: CCDC136 CDKN2A CEP70 HAP1 MDM2 PPP1CA PSMA1 SPTBN1 SRPK2 TP53 TSPYL2 UPF2	76 interacting genes: ABCF2 AGPAT1 AKTIP ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44
Entrez ID		29997	26019
HPRD ID		16142	10405
Ensembl ID		ENSG00000105373	ENSG00000151461
Uniprot IDs		Q9NZM5	Q9HAU5
PDB IDs			1UW4 2WJV 4CEK 4CEM
Enriched GO Terms of Interacting Partners?
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