SELPLG and CIT

Data Source:
BioGRID (affinity chromatography technology)

		SELPLG	CIT
Description		selectin P ligand	citron rho-interacting serine/threonine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Uropod Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Plasma Membrane Raft	Cytoplasm Cytosol Cytoskeleton Membrane
	Molecular Function	Virus Receptor Activity Signaling Receptor Binding Protein Binding	Transcription Coactivator Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding SH3 Domain Binding Protein Kinase Binding PDZ Domain Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Cell Adhesion Hemopoiesis Viral Entry Into Host Cell Leukocyte Migration Leukocyte Tethering Or Rolling Leukocyte Adhesive Activation Cellular Response To Interleukin-6	Mitotic Cell Cycle Mitotic Cytokinesis Peptidyl-threonine Phosphorylation Actomyosin Structure Organization Positive Regulation Of Cytokinesis Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Generation Of Neurons Neuron Apoptotic Process Negative Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Cell surface interactions at the vascular wall	RHO GTPases activate CIT RHO GTPases activate CIT
Drugs			Fostamatinib
Diseases
GWAS		Acne (severe) ( 24927181) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Conduct disorder (symptom count) ( 20585324)	Number of sexual partners ( 30643258) Urgency urinary incontinence ( 25524241)
Interacting Genes		14 interacting genes: BACE1 CTSG GALNT4 MAGEA1 MSN SELE SELL SELP SLC13A1 SYK TNIP1 TPST1 TPST2 VCAN	10 interacting genes: DISC1 DLG4 GRIN1 GRIN2D MTNR1A RAC1 RHOA RHOB RHOC RND3
Entrez ID		6404	11113
HPRD ID		02845	09289
Ensembl ID		ENSG00000110876	ENSG00000122966
Uniprot IDs		Q14242	O14578
PDB IDs		1G1S
Enriched GO Terms of Interacting Partners?
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